Anti-inflammatory response of an aerobic rehabilitation session with electrical stimulation in rats induced with myocardial infarction

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

Assistant Professor, Department of Exercise Physiology, Arak Branch, Islamic Azad University, Arak, Iran

Abstract

Aim: Pentraxin-3 and E-selectin glycoproteins are synthesized by endothelium cells, macrophages and myeloid cells during inflammation and play an essential role in heart attack patients. Considering the positive effects of aerobic rehabilitation on heart patients, the present research has investigated the anti-inflammatory response of an aerobic rehabilitation session accompanied by electrical stimulation in rats induced to myocardial infarction. Methods: In this controlled experimental study with a control group, 50 rats (200±30 gram) were randomly divided into 5 groups: healthy, infarcted, infarcted-aerobic rehabilitation, infarcted-electrical stimulation, and infarcted-aerobic rehabilitation-electrical stimulation. Then infarction was induced by subcutaneous injection of Isoproterenol. The intervention groups underwent aerobic rehabilitation (treadmill at a speed of 20 m/min for 1 hour) and electrical stimulation (with foot shock for 0.5 mA and 20 minutes) for one session. Then, immediately after the intervention, the serum levels of the variables were checked by ELISA method. Data analysis was done with one-way ANOVA test and P<0.05 significance. Results: The results showed that infarct induction led to a significant increase in pentraxin-3 and E-Selectin serum levels in the present study (P=0.0001). Performing rehabilitation and a combination of rehabilitation and electrical stimulation had no significant effect on pentraxin-3 values (P=0.943). But E-selectin concentration was decreased in all groups compared to infarction, and this change was significant in rehabilitation and electrical stimulation group (P=0.044). Conclusion: It seems that aerobic rehabilitation, electrical stimulation, and a combination of them by reducing E-selectin levels can be effective in improving the condition of myocardial infarction samples by reducing inflammation.

Keywords

References

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Journal of Applied Health Studies in Sport Physiology
Volume 10, Issue 2
August 2023
Pages 139-150

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History

  • Receive Date: 07 April 2023
  • Revise Date: 20 July 2023
  • Accept Date: 20 July 2023

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