The effect of multicomponent training (aerobic, resistance and balance) on galectin-3, cardiovascular risk factors and psychological well-being in overweight elderly

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Assistant Professor of department of Physical Education, Birjand Branch, Islamic Azad University, Birjand, Iran

2 Assistant Professor of department of Sport Sciences, Faculty of Literature and Humanities, University of Zabol, Zabol, Iran

3 Master of physical education, Birjand, Iran

4 Master of physical education, Birjand , Iran

Abstract

The increase of galectin-3 and disturbance in the lipid profile are considered as risk factors for cardiac events in old age, and exercise has been proposed as a modulating solution to this situation. The aim of this study was to investigate the effect of eight weeks of multicomponent training elderly. Methods: In this s Quasi -experimental study, 40 inactive overweight elderly men with an age range of 60 to 75 years were selected using a targeted and accessible sampling method and were randomly assigned to two training and control groups. Multicomponent training including aerobic (40 to 65% of maximum heart rate), resistance (5 to 8 pressure perception according to OMNI) and balance sections was performed for eight weeks (3 sessions per week).  Galectin-3 by ELISA method, lipid profile by enzymatic method and psychological well-being by Riff questionnaire were measured.  Data were measured using independent t-tests, analysis of covariance and Pearson correlation. Results: Eight weeks of multicomponent training caused a significant decrease in galectin-3 (P=0.01), TG (P=0.001), TC (P=0.01), LDL (P=0.001), WHR (P=0.01), fat percentage (P=0.01) and a significant increase in HDL (P=0.01) and psychological well-being (P=0.01). Also, there was a positive correlation between the psychological well-being score with HDL (P=0.01) and an inverse correlation with Galectin-3 (P=0.01) and LDL (P=0.03). Conclusions: Multicomponent training seem to reduce the risk of cardiovascular diseases and cognitive disorders in the elderly by improving body composition and reducing galectin-3, fibrinogen, and blood lipids.  

Keywords

References

  1. Costantino S, Paneni F, Cosentino F. Ageing, metabolism and cardiovascular disease. The Journal of physiology 2016;594(8):2061-2073.
  2. Krakowiak J, Raczkiewicz D, Wdowiak A, Cichońska D, Bojar I. Atherogenic lipid profile and health behaviours in women post-menopause working in agriculture. Annals of Agricultural and Environmental Medicine 2019;26(4).
  3. Ramos LR, Gravina CF, Pithon Curi TC, Vaisberg M, Maranhão RC. Exercise training improves plasma lipid and inflammatory profiles and increases cholesterol transfer to high-density lipoprotein in elderly women. Journal of the American Geriatrics Society 2015:1247-1248.
  4. Ghasemi E, Nayebifar S. Benefits of 10 weeks of high-intensity interval training and green tea supplementation on cardiovascular risk factors and VO2max in overweight women. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences 2019;24.
  5. Einollahi N, Haghshenas E, Allami AH, Nikvand F. Review of biochemical biomarkers in cardiovascular diseases. Laboratory & Diagnosis 2019;10(42):49-57. [In Persian]
  6. Ho JE, Liu C, Lyass A, Courchesne P, Pencina MJ, Vasan RS, et al. Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community. Journal of the American College of Cardiology 2012;60(14):1249-1256.
  7. Avazpour S, Nemati J, Dejbakht M. Effect of a period of combined and interval training on C Reactive protein and galactin levels in coronary heart disease. 2022. Research in Medicine 2022; 46 (2) :40-49. [In Persian]
  8. Zeng N, Wang A, Xu T, Zhong C, Zheng X, Zhu Z, et al. Co-effect of serum galectin-3 and high-density lipoprotein cholesterol on the prognosis of acute ischemic stroke. Journal of Stroke and Cerebrovascular Diseases 2019;28(7):1879-1885.
  9. Cao Z-Q, Yu X, Leng P. Research progress on the role of gal-3 in cardio/cerebrovascular diseases. Biomedicine & Pharmacotherapy 2021;133:111066.
  10. Mohammadi N, Aghayousefi A, Alipour A, Sadeghi M, Nikrahan G, Roohafza H. The role of psychological well-being indicators in predicting metabolic risk factors in the patients with chronic coronary heart disease. Positive Psychology Research 2017;3(3):17-32. [In Persian]
  11. Ranjbaran R, Aliakbari Dehkordi M, Saffarinia M, Alipour A. Effect of health promoting lifestyle training on vitality, psychological well-being and blood pressure of women with cardiovascular disease. Cardiovascular Nursing Journal 2019;8(1):98-109. [In Persian]
  12. Cordes T, Bischoff LL, Schoene D, Schott N, Voelcker-Rehage C, Meixner C, et al. A multicomponent exercise intervention to improve physical functioning, cognition and psychosocial well-being in elderly nursing home residents: a study protocol of a randomized controlled trial in the PROCARE (prevention and occupational health in long-term care) project. BMC geriatrics 2019;19:1-11.
  13. Saadeh M, Welmer A-K, Dekhtyar S, Fratiglioni L, Calderón-Larrañaga A. The role of psychological and social well-being on physical function trajectories in older adults. The Journals of Gerontology: Series A 2020;75(8):1579-1585.
  14. Gholaman M, Gholami M, Azarbayjani MA, Abed Natanzi H. High and Moderate Intensity Aerobic Training Effects on Galectin-3, Pentraxin-3, and Several Inflammatory Mediators Levels in Type 2 Diabetic Women, a Randomized Clinical Trial. Women’s Health Bulletin 2021;8(4):238-246.
  15. Billebeau G, Vodovar N, Sadoune M, Launay J-M, Beauvais F, Cohen-Solal A. Effects of a cardiac rehabilitation programme on plasma cardiac biomarkers in patients with chronic heart failure. European journal of preventive cardiology 2017;24(11):1127-1135.
  16. Khajeian N, Moghadasi M. Effect of 8 weeks regular endurance training on galectin-3 changes after a strenuous aerobic exercise. Journal of Physical Activity and Hormones 2017;1(3):29-38.
  17. Bachi AL, Barros MP, Vieira RP, Rocha GA, de Andrade P, Victorino AB, et al. Combined exercise training performed by elderly women reduces redox indexes and proinflammatory cytokines related to atherogenesis. Oxidative Medicine and Cellular Longevity 2019;2019.
  18. Andonian BJ, Bartlett DB, Huebner JL, Willis L, Hoselton A, Kraus VB, et al. Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes. Arthritis research & therapy 2018;20:1-9.
  19. Fernandes-Silva MM, Guimarães GV, Rigaud VO, Lofrano-Alves MS, Castro RE, de Barros Cruz LG, et al. Inflammatory biomarkers and effect of exercise on functional capacity in patients with heart failure: Insights from a randomized clinical trial. European journal of preventive cardiology 2017;24(8):808-817.
  20. Roh H-T, Cho S-Y, So W-Y. A cross-sectional study evaluating the effects of resistance exercise on inflammation and neurotrophic factors in elderly women with obesity. Journal of clinical medicine 2020;9(3):842.
  21. Chodzko-Zajko WJ, Proctor DN, Singh MAF, Minson CT, Nigg CR, Salem GJ, et al. Exercise and physical activity for older adults. Medicine & science in sports & exercise 2009;41(7):1510-1530.
  22. Sadjapong U, Yodkeeree S, Sungkarat S, Siviroj P. Multicomponent exercise program reduces frailty and inflammatory biomarkers and improves physical performance in community-dwelling older adults: A randomized controlled trial. International journal of environmental research and public health 2020;17(11):3760.
  23. Colado JC, Garcia-Masso X, Triplett TN, Flandez J, Borreani S, Tella V. Concurrent validation of the OMNI-resistance exercise scale of perceived exertion with Thera-band resistance bands. The Journal of Strength & Conditioning Research 2012;26(11):3018-3024.
  24. Jackson AS, Pollock ML, Ward A. Generalized equations for predicting body density of women. Medicine and science in sports and exercise 1980;12(3):175-181.
  25. Triado C, Villar F, Solé C, Celdrán M. Construct validity of Ryff's scale of psychological well-being in Spanish older adults. Psychological reports 2007;100(3_suppl):1151-1164.
  26. Hättasch R, Spethmann S, de Boer RA, Ruifrok WP, Schattke S, Wagner M, et al. Galectin-3 increase in endurance athletes. European Journal of Preventive Cardiology 2014;21(10):1192-1199.
  27. Sayed A, Munir M, Nabet MS, Alghamdi BS, Ashraf GM, Bahbah EI, et al. Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis. Mediators of Inflammation 2022;2022.
  28. Smereczyńska-Wierzbicka E, Pietrzak R, Werner B. A Scoping Review of Galectin-3 as a Biomarker of Cardiovascular Diseases in Pediatric Populations. International Journal of Environmental Research and Public Health 2022;19(7):4349.
  29. Pei C, Zhang Y, Wang P, Zhang B, Fang L, Liu B, et al. Berberine alleviates oxidized low‐density lipoprotein‐induced macrophage activation by downregulating galectin‐3 via the NF‐κB and AMPK signaling pathways. Phytotherapy Research 2019;33(2):294-308.
  30. Ghamarchehreh ME, Shamsoddini A, Alavian SM. Investigating the impact of eight weeks of aerobic and resistance training on blood lipid profile in elderly with non-alcoholic fatty liver disease: a randomized clinical trial. Gastroenterology and hepatology from bed to bench 2019;12(3):190.
  31. Ruangthai R, Phoemsapthawee J. Combined exercise training improves blood pressure and antioxidant capacity in elderly individuals with hypertension. Journal of Exercise Science & Fitness 2019;17(2):67-76.
  32. Diniz TA, Rossi FE, Fortaleza ACS, Neves LM, Christofaro DGD, Buonani C, et al. Changes in HDL-c concentrations after 16 weeks of combined training in postmenopausal women: characteristics of positive and negative responders. Applied Physiology, Nutrition, and Metabolism 2018;43(1):38-44.
  33. Pedersen LR, Olsen RH, Anholm C, Astrup A, Eugen-Olsen J, Fenger M, et al. Effects of 1 year of exercise training versus combined exercise training and weight loss on body composition, low-grade inflammation and lipids in overweight patients with coronary artery disease: a randomized trial. Cardiovascular diabetology 2019;18(1):1-13.
  34. Guo Y, Li P, Ma X, Huang X, Liu Z, Ren X, et al. Association of circulating cholesterol level with cognitive function and mild cognitive impairment in the elderly: a community-based population study. Current Alzheimer Research 2020;17(6):556-565.
  35. Mijailović NR, Vesic K, Arsenijevic D, Milojević-Rakić M, Borovcanin MM. Galectin-3 Involvement in Cognitive Processes for New Therapeutic Considerations. Frontiers in cellular neuroscience 2022;16:923811.
  36. Bates KA, Sohrabi HR, Rainey-Smith SR, Weinborn M, Bucks RS, Rodrigues M, et al. Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women. International Journal of Neuroscience 2017;127(3):243-252.
  37. Jansen P, Dahmen-Zimmer K. Effects of cognitive, motor, and karate training on cognitive functioning and emotional well-being of elderly people. Frontiers in psychology 2012;3:40.
Journal of Applied Health Studies in Sport Physiology
Volume 10, Issue 2
August 2023
Pages 54-67

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History

  • Receive Date: 08 January 2023
  • Revise Date: 18 May 2023
  • Accept Date: 22 May 2023

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