The effects of 12 weeks of aerobic exercise and ketogenic diet on secreted frizzled-related protein 5 (SFRP5) levels and metabolic factors in middle-aged men with metabolic syndrome: A double blind placebo-controlled parallel group study

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Associate Professor of Azarbaijan Shahid Madani University, Tabriz, Iran

2 Department of Health and Human Performance, Marymount University, Arlington, VA, United States

3 Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, Mohaghegh Ardabili University, Ardabil, Iran

Abstract

Aim:   The aim of this study was to investigate the effect of 12 weeks of aerobic exercise combined with a ketogenic diet on Secreted frizzled-related protein 5 (SFRP5) levels and metabolic syndrome factors in middle-aged men with metabolic syndrome. Methods: 40 middle-aged men with metabolic syndrome were randomly divided into control (n = 10), aerobic exercise (n = 10), ketogenic diet (n = 10), and aerobic exercise and ketogenic diet (n = 10) groups. The intervention groups performed aerobic exercise and ketogenic diet control for 12 weeks.  In the pre-test stages and after 12 weeks, SFRP5 protein levels and metabolic syndrome factors (fasting glucose, lipid profile, blood pressure and waist circumference) were evaluated in four study groups. Results:  In between-group comparison, the group of aerobic exercise combined with ketogenic diet caused a significant increase in SFRP5 (p=0.04) in middle-aged men with metabolic syndrome compared to the control group. The comparison of other groups in this index did not show any significant difference from each other (p≤0.05). In within-group comparison, the results showed that in all three intervention groups, the level of SFRP5 (aerobic exercise group: p=0.001; ketogenic diet group: p=0.001; and aerobic exercise group with ketogenic diet p=0.001) had a significant increase and the highest increase was in the aerobic exercise group with ketogenic diet. Conclusions: Aerobic exercise combined with a ketogenic diet has better effects than a single aerobic exercise and ketogenic diet to control metabolic risks in middle-aged men with metabolic syndrome.
 

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References

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Journal of Applied Health Studies in Sport Physiology
Volume 12, Issue 1
March 2025
Pages 13-27

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History

  • Receive Date: 23 January 2023
  • Revise Date: 17 March 2023
  • Accept Date: 18 March 2023

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