The effect of 12 weeks of high-intensity interval training and curcumin consumption on glycemic index, adiponectin and lipid profile in obese men with type2 diabetes hyperlipidemia

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Associate Professor, Department of Exercise Physiology, Faculty of Humanities and Social, Ardakan University, Ardakan, Iran.

2 Department of Physical Education and sport science, Technical and Vocational University (TVU), Tehran, Iran.

3 PhD of exercise physiology, Department of Physical Education, Tabriz branch, islamic azad university, tabriz, Iran.

Abstract

Aim:   Physical exercises and the consumption of medicinal plants with anti-inflammatory properties are one of the most widely used methods to reduce the complications of type 2 diabetes. The aim of this study was to investigate the interactive effect of 12 weeks of high-intensity interval training and curcumin consumption on glycemic index, adiponectin and lipid profile in obese men with type2 diabetes hyperlipidemia. Methods: The current research was a double-blind semi-experimental type. The statistical population included men with type 2 diabetes (mean age 38.76±2.05 years and weight 89.00±2.96 kg), 60 people participated in this research. Subjects were randomly divided into four groups: high-intensity interval training, high-intensity interval training + curcumin, curcumin, and placebo-control. The training intervention was performed three times a week and the consumption daily of curcumin was 2100 mg in three servings of 700 mg, for 12 weeks. Body composition and biochemical indices were measured before and after exercise. One-way ANOVA, two-way factorial ANOVA for repeated measurements and paired samples t test were used to analyze the data. Results: Interactive effect of exercise and curcumin significantly increased adiponectin (p= 0.010), and significantly decreased glucose (p= 0.0001), insulin (p= 0.0001), HbA1c (p= 0.021), insulin resistance (p= 0.001), TC (p= 0.0001), TG (p= 0.001), LDL (p= 0.002) and HDL (p= 0.011). Exercise alone caused significant changes in all biochemical variables (p<0.05), but curcumin consumption alone did not cause significant changes (P>0.05). Conclusions: Therefore, high-intensity interval training with curcumin consumption more improved glycemic status and lipid profiles in hyperlipidemia type 2 diabetes men more than the main effect of training and curcumin.

Keywords

Main Subjects

Publisher: Azarbaijan Shahid Madani University          Copyright © The Authors   

   

 

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

References

  1. Samudera WS, Efendi F, Indarwati R. Effect of community and peer support based healthy lifestyle program (CP-HELP) on self care behavior and fasting blood glucose in patient with type 2 Diabetes Mellitus. Journal of Diabetes & Metabolic Disorders. 2021;20(1):193-9.
  2. Kao H-H, Hsu H-S, Wu T-H, Chiang H-F, Huang H-Y, Wang H-J, et al. Effects of a single bout of short-duration high-intensity and long-duration low-intensity exercise on insulin resistance and adiponectin/leptin ratio. Obesity Research & Clinical Practice. 2021;15(1):58-63
  3. Sokolovska J, Ostrovska K, Pahirko L, Varblane G, Krilatiha K, Cirulnieks A, et al. Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes. Physiological reports. 2020;8(13):e14506.
  4. Jimenez-Maldonado A, Virgen-Ortiz A, Lemus M, Castro-Rodríguez E, Cerna-Cortés J, Muñiz J, et al. Effects of moderate-and high-intensity chronic exercise on the adiponectin levels in slow-twitch and fast-twitch muscles in rats. Medicina. 2019;55(6):291.
  5. Fakhri F, Shakeryan S, Fakhri S, Alizadeh A. The effect of 6 weeks of high intensity interval training (HIIT) with nano-curcumin supplementation on factors related to cardiovascular disease in inactive overweight girls. KAUMS Journal (FEYZ). 2020;24(2):181-9. [In presian]
  6. Darmian MA, Hoseini R, Amiri E, Golshani S. How Combined and Separate Aerobic Training and Turmeric Supplementation Alter Lipid Profile and Glycemic Status? A Clinical Trial in Middle-Aged Females with Type 2 Diabetes and Hyperlipidemia. International Cardiovascular Research Journal. 2021;15(3):111-118.
  7. Sedaghat H, Fattahi Bafghi A, Emami A. The effect of combined exercise training course with curcumin supplementation on lipid profiles of inactive middle-aged men. Iranian Journal of Diabetes and Obesity. 2018;10(2):61-6.
  8. Wickenberg J, Ingemansson S. L, Hlebowicz J. Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutr J. 2010;9(43):1-5.
  9. Shao W, Yu Z, Chiang Y,Yang Y, Chai T, Foltz W, Lu H, Fantus I. G, Jin T. Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes. PLoS One. 2012;7(1): e28784
  10. Cassidy S, Thoma C, Houghton D, Trenell M I. High-intensity interval training: a review of its impact on glucose control and cardiometabolic healt. Diabetologia.2017;60: 7–23.
  11. He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. Curcumin, inflammation, and chronic diseases: How are they linked? Molecules. 2015;20(5):9183-213.
  12. Jimenez-Osorio AS, Monroy A, Alavez S. Curcumin and insulin resistance Molecular targets and clinical evidences. BioFactors. 2016;42(6):561-80.
  13. Darmian MA, Hoseini R, Amiri E, Golshani S. Downregulated hs-CRP and MAD, upregulated GSH and TAC, and improved metabolic status following combined exercise and turmeric supplementation: a clinical trial in middle-aged women with hyperlipidemic type 2 diabetes. Journal of Diabetes & Metabolic Disorders. 2022:1-9.
  14. Jimenez-Maldonado A, García-Suárez PC, Rentería I, Moncada-Jiménez J, Plaisance EP. Impact of high-intensity interval training and sprint interval training on peripheral markers of glycemic control in metabolic syndrome and type 2 diabetes. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2020;1866(8):165820.
  15. Boutcher SH. High-intensity intermittent exercise and fat loss. J Obes. 2011; 2011: 1-10.
  16. Almenning I, Rieber-Mohn A, Lundgren KM, Shetelig Lovvik T, Garnaes K, Moholdt T. Effects of high intensity interval training and strength training on metabolic, cardiovascular and hormonal outcomes in women with polycystic ovary syndrome: A pilot study. PLoS One. 2015;10(9): e0138793.
  17. Skleryk JR, Karagounis LG, Hawley JA, Sharman MJ, Laursen PB, et al. Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men. Diabetes, Obes. Metab. 2013; 15:1146-53
  18. Zhang H, Tong TK, Qiu W, Wang J, Nie J, He Y. Effect of high intensity interval training protocol on abdominal fat reduction in overweight chinese women. Kinesiology. 2015;47(1):57-66.
  19. Batrakoulis A, Fatouros IG, Chatzinikolaou A, Draganidis D, Georgakouli K, Papanikolaou K, et al. Dose-response effects of high-intensity interval neuromuscular exercise training on weight loss, performance, health and quality of life in inactive obese adults: Study rationale, design and methods of the DoIT trial. Contemporary clinical trials communications. 2019;15:100386.
  20. Bahram ME, Pourrahim Ghouroghch A, Pourvaghar MJ, Ghyiami Taklimi H. Effect of 8-weeks High Intensity Interval Training on Adiponectin Plasma Level, Insulin, Insulin Resistance and Glucose in Overweight Young Men. Sport Physiology & Management Investigations. 2021;12(4):141-51. [In presian]
  21. Basu A, Lyons TJ. Antioxidants, oxidative stress, and preeclampsia in diabetes. Diabetes: Elsevier; 2020. p. 151-9.
  22. Daneshzad E, Farsad-Naeimi A, Heshmati J, Mirzaei K, Maghbooli Z, Keshavarz S-A. The association between dietary antioxidants and adipokines level among obese women. Diabetes & Metabolic Syndrome. Clinical Research & Reviews. 2019;13(2):1369-73.
  23. Khadem Haghighian H, Farsad Naimi A, Pourghassem Gargari B, Ali-Asgharzadeh A, Nemati A. Effect of cinnamon supplementation on blood glucose and lipid levels in type2 diabetic patients. Arch Adv Biosci.2011;2(1):1-5.
  24. Naghizadeh, H., Heydari, F. The effect of 12 weeks of HIIT and curcumin consumption on oxidative indices in obese men with type-2 diabetes mellitus. Journal of Sport and Exercise Physiology, 2022; 15(4): 67-81. doi: 10.52547/joeppa.15.4.67. [In presian]
  25. Bengmark S, Mesa MD, Gil A. Plant-derived health-the effects of turmeric and curcuminoids. Nutricion hospitalaria. 2009;24(3):273-81.
  26. Khajehdehi P, Zanjaninejad B, Aflaki E, Nazarinia M, Azad F, Malekmakan L, et al. Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled study. Journal of Renal Nutrition. 2012;22(1):50-7.
  27. Rostami Hashjin Z, Amirsasan R, Nikookheslat S, Sari-Sarraf V. Effect of High Intensity Interval Training with Turmeric Supplementation on Visceral Fat, Subcutaneous Abdominal Fat and Insulin Resistance in Obese Females. Sport Physiology. 2019;11(43):55-74. [In presian]
  28. Serrablo-Torrejon I, Lopez-Valenciano A, Ayuso M, Horton E, Mayo X, Medina-Gomez G, et al. High intensity interval training exercise-induced physiological changes and their potential influence on metabolic syndrome clinical biomarkers: a meta-analysis. BMC Endocrine Disorders. 2020;20(1):1-12.
  29. Zheng L, Rao Z, Guo Y, Chen P, Xiao W. High-intensity interval training restores glycolipid metabolism and mitochondrial function in skeletal muscle of mice with type 2 diabetes. Frontiers in Endocrinology. 2020;11.
  30. Winding KM, Munch GW, Iepsen UW, Van Hall G, Pedersen BK, Mortensen SP. The effect on glycaemic control of low‐volume high‐intensity interval training versus endurance training in individuals with type 2 diabetes. Diabetes, Obesity and Metabolism. 2018;20(5):1131-9.
  31. Maillard F, Rousset S, Pereira B, Traore A, Del Amaze PdP, Boirie Y, et al. High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes. Diabetes & metabolism. 2016;42(6):433-41.
  32. Li J, Li Y, Atakan MM, Kuang J, Hu Y, Bishop DJ, et al. The molecular adaptive responses of skeletal muscle to high-intensity exercise/training and hypoxia. Antioxidants. 2020;9(8):656
  33. Lao CD, Ruffin MT, Normolle D, Heath DD, Murray SI, Bailey JM, et al. Dose escalation of a curcuminoid formulation. BMC complementary and alternative medicine. 2006:6(10):4-1.
  34. Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes care. 2012;35(11):2121-7.
  35. Pivari F, Mingione A, Brasacchio C, Soldati L. Curcumin and type 2 diabetes mellitus: prevention and treatment. Nutrients. 2019;11(8):1837.
  36. Lu X, Wu F, Jiang M, Sun X, Tian G. Curcumin ameliorates gestational diabetes in mice partly through activating AMPK. Pharmaceutical biology. 2019;57(1):250-4.
  37. Mohammed A, Islam MS. Spice-derived bioactive ingredients: potential agents or food adjuvant in the management of diabetes mellitus. Frontiers in pharmacology. 2018;9:893.
  38. Altobelli E, Angeletti PM, Marziliano C, Mastrodomenico M, Giuliani AR, Petrocelli R. Potential Therapeutic Effects of Curcumin on Glycemic and Lipid Profile in Uncomplicated Type 2 Diabetes—A Meta-Analysis of Randomized Controlled Trial. Nutrients. 2021;13(2):404.
  39. Marton LT, Pescinini-e-Salzedas LM, Camargo MEC, Barbalho SM, Haber JFdS, Sinatora RV, et al. The effects of curcumin on diabetes mellitus: a systematic review. Frontiers in Endocrinology. 2021;12:669448.
  40. Hosseini M, Eftekhar B, Riyahi Malayeri S. Effect of interval training with curcumin consumption on some adipokines in menopausal obese rats. Journal of Rafsanjan University of Medical Sciences. 2017;16(6):505-16. [In presian]
  41. Bateni Z, Behrouz V, Rahimi HR, Hedayati M, Afsharian S, Sohrab G. Effects of nano-curcumin supplementation on oxidative stress, systemic inflammation, adiponectin, and NF-κB in patients with metabolic syndrome: A randomized, double-blind clinical trial. Journal of Herbal Medicine. 2022;31:100531
  42. Panahi Y, Hosseini MS, Khalili N, Naimi E, Soflaei SS, Majeed M, et al. Effects of supplementation with curcumin on serum adipokine concentrations: a randomized controlled trial. Nutrition. 2016;32(10):1116-22
  43. Neerati P, Devde R, Gangi AK. Evaluation of the effect of curcumin capsules on glyburide therapy in patients with type‐2 diabetes mellitus. Phytotherapy Research. 2014;28(12):1796-800.
  44. Na LX, Li Y, Pan HZ, Zhou XL, Sun DJ, Meng M, et al. Curcuminoids exert glucose‐lowering effect in type 2 diabetes by decreasing serum free fatty acids: A double‐blind, placebo‐controlled trial. Molecular nutrition & food research. 2013;57(9):1569-77.
  45. Aghapoor A, Ahmadizad S, Basami M, Dolataabadi P. The Effects of different protocols of isocaloric interval and continuous endurance exercise on fat metabolism. Journal of Applied Health Studies in Sport Physiology. 2022; 9(2): 61-71. [In presian].
Journal of Applied Health Studies in Sport Physiology
Volume 10, Issue 1
April 2023
Pages 50-66

Files

History

  • Receive Date: 04 October 2022
  • Revise Date: 15 December 2022
  • Accept Date: 27 December 2022

Share

How to cite

Statistics