Investigation the effect of Moderate intensity aerobic exercise and intense periodic exercise on adropine serum levels and its relationship with lipid profile in overweight men

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Department of Exercise Physiology, Eslamabad-E-Gharb Branch, Islamic Azad University, Eslamabad-E-Gharb, Iran

2 Department of Exercise Physiology , Gilan - E-Gharb Branch, Islamic Azad University, Gilan-E- Gharb, Iran

Abstract

Aim:  Obesity and being overweight are the main causes of metabolic disorders like diabetes, hypertension, and cardiovascular disease. Adropine mediates exercise-induced changes and, in parallel, reduces the oxidation of muscle fatty acids, which can lead to a reduction in exercise-induced vascular stiffness. Therefore, the aim of this study was to compare and evaluate the effects of intense periodic aerobic exercise and intense intermittent exercise on adropine serum levels and their relationship with the lipid profile in overweight men. Methods:  A total of 24 overweight young men, ranging in age from 25 to 35 years, were randomly selected as a sample in 3 groups, with 8 people each for aerobic exercise, intense intermittent exercise, and control. Both types of exercises were performed for 6 weeks, 3 sessions per week, and 45 to 65 minutes per session. Before and after the training interventions, blood samples were collected to measure and calculate the adropine serum levels and lipid profile in the 12-hour fasting state. Results: 6 weeks of moderate-intensity aerobic exercise and intense interval exercise resulted in a significant increase in adropine (P=0.006) and HDL (P=0.001) as well as a significant decrease in triglycerides (P=0.002), cholesterol (P=0.017), LDL(P=0.001)  of overweight men .Also, there was a significant negative relationship between changes in adropine with triglycerides(P=0.002), cholesterol(P=0.017), and LDL(P=0.001), and a significant positive relationship between changes in adropine and HDL. Conclusions: Aerobic exercise and interval exercise improving the lipid profile in overweight men, by reducing the lipid profile, it can be said that risk of cardiovascular disease is reduced. Adropine appears to play a role in these exercise induced changes. Therefore, special attention should be paid to the mediator role of adropine in these changes resulting from exercise.

Keywords

Main Subjects

   

 

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

References

  1. Sharma A. Obesity and cardiovascular risk. Growth Hormone & IGF Research. 2003;13:S10-S7.
  2. Janghorbani M, Amini M, Willett WC, Gouya MM, Delavari A, Alikhani S, & Mahdavi A. (2007). First nationwide survey of prevalence of overweight, underweight, and abdominal obesity in Iranian adults. Obesity. 15(11); PP: 2797-808.
  3. Sharma S, Bakshi R, Tandon VR, Mahajan A. Postmenopausal obesity. Climacteric. 2007;10(1):19-24.
  4. Braith RW, Stewart KJ. Resistance exercise training: its role in the prevention of cardiovascular disease. Circulation. 2006;113(22):2642-50.
  5. Zderic TW, Hamilton MT. Physical inactivity amplifies the sensitivity of skeletal muscle to the lipid-induced downregulation of lipoprotein lipase activity. Journal of Applied Physiology. 2006;100(1):2.49-57.
  6. Delecluse C, Colman V, Roelants M, Verschueren S, Derave W, Ceux T, et al. Exercise programs for older men: mode and intensity to induce the highest possible health-related benefits. Preventive Medicine. 2004;39(4):823-33.
  7. Kaka R, Ghaedi H, Farsi S, Taghipour Asrami A. The Effect of Nonlinear Resistance Training with Supplementation of Spirulina on serum Leptin and Ghrelin in obese women. Journal of Applied Health Studies in Sport Physiology. 2019;6(1):69-77(1).
  8. Braith RW, Beck DT. Resistance exercise: training adaptations and developing a safe exercise prescription. Heart failure reviews. 2008;13(1):69-79.
  9. Duncan GE, Anton SD, Sydeman SJ, Newton RL, Corsica JA, Durning PE, et al. Prescribing exercise at varied levels of intensity and frequency: a randomized trial. Archives of internal medicine. 2005; 165 (20):2362-9.
  10. Kazeminasab, F. (2022). The effect of eight weeks of aerobic exercise and resveratrol on expression of genes involved in thermogenesis and lipid profile in male C57BL/6 mice. Journal of Applied Health Studies in Sport Physiology, 9(1), 164-175. doi: 10.22049/ jahssp. 2022. 27762.1459. [In Persian]
  11. Elliott K, Sale C, Cable N. Effects of resistance training and detraining on muscle strength and blood lipid profiles in postmenopausal women. British journal of sports medicine. 2002;36(5):340-4.
  12. Marczuk N, Cecerska-Heryć E, Jesionowska A, Dołęgowska B. Adropin-physiological and pathophysiological role. Advances in Hygiene & Experimental Medicine/Postepy Higieny i Medycyny Doswiadczalnej. 2016;70.
  13. Gao S, McMillan RP, Jacas J, Zhu Q, Li X, Kumar GK, et al. Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin. Diabetes. 2014;63(10):3242-52.
  14. Zhang H, Jiang L, Yang Y-J, Ge R-K, Zhou M, Hu H, et al. Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss. Scientific reports. 2017;7(1):1-8.
  15. Fujie S, Hasegawa N, Sato K, Fujita S, Sanada K, Hamaoka T, et al. Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults. American Journal of Physiology-Heart and Circulatory Physiology. 2015;309(10):H1642-H7.
  16. Abbasian S, Ravasi A A, Soori R, Choobineh S. The effect of high intensity interval training on Adropin and Nitric Oxide metabolites in over weight men. 2022; J Arak Uni Med Sci; 25 (2) URL: http://jams.arakmu.ac.ir/article-1-70 75-fa.html. [In Persian]
  17. Gibala MJ, Little JP, MacDonald MJ, Hawley JA. Physiological adaptations to low‐volume, high‐intensity interval training in health and disease. The Journal of physiology. 2012;590(5):1077-84.
  18. Lazzer S, Tringali G, Caccavale M, De Micheli R, Abbruzzese L, Sartorio A. Effects of high-intensity interval training on physical capacities and substrate oxidation rate in obese adolescents. Journal of endocrinological investigation. 2017;40(2):217-26.
  19. Czarkowska-Paczek B, Bartlomiejczyk I, Gabrys T, Przybylski J, Nowak M, Paczek L. Lack of relationship between interleukin-6 and CRP levels in healthy male athletes. Immunology letters. 2005;99(1):136-40.
  20. Bermingham MA, Mahajan D, Neaverson MA. Blood lipids of cardiac patients after acute exercise on land and in water. Archives of physical medicine and rehabilitation. 2004;85(3):509-11.
  21. Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, et al. Effects of the amount and intensity of exercise on plasma lipoproteins. New England Journal of Medicine. 2002;347(19):1483-92.
  22. Theodorou AA, Panayiotou G, Volaklis KA, Douda HT, Paschalis V, Nikolaidis MG, et al. Aerobic, resistance and combined training and detraining on body composition, muscle strength, lipid profile and inflammation in coronary artery disease patients. Research in sports medicine. 2016;24(3):171-84.
  23. Baker J, Davies B. High intensity exercise assessment: relationships between laboratory and field measures of performance. Journal of Science and Medicine in Sport. 2002;5(4):341-7.
  24. Burgomaster KA, Hughes SC, Heigenhauser GJ, Bradwell SN, Gibala MJ. Six sessions of sprint interval training increases muscles oxidative potential and cycle endurance capacity in humans. Journal of applied physiology. 2005; 98(6): 1985-90.
  25. Aydin S, Kuloglu T, Aydin S, Eren MN, Yilmaz M, Kalayci M, et al. Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes. Molecular and cellular biochemistry. 2013; 380 (1):73-81.
  26. Wong C-M, Wang Y, Lee JTH, Huang Z, Wu D, Xu A, et al. Adropin is a brain membrane-bound protein regulating physical activity via the NB-3/Notch signaling pathway in mice. Journal of Biological Chemistry. 2014;289 (37): 259 76-86.
  27. Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta M, et al. Adropin is a novel regulator of endothelial function. Circulation. 2010; 122 (11_suppl_1):S185-S92.
  28. Hosseini H, Abedi B, Fatolahi H. The Effect of Aerobic water-based training on Adropin levels, insulin resistance and Lipid profile in ageing Men. yafte 2019; 21 (1) :99-110 .URL :http: //yafte. lu ms.ac.ir / article-1-2776-fa. html.[In Persian]
  29. Dolataabadi P, Amirsasan R, Vakili J. The effect of high-intensity interval training on lipid profile of overweight and obese Women. 2022; 18 July. 22077/JPSBS. 2022.5292.1714.
  30. Celik A, Balin M, Kobat MA, Erdem K, Baydas A, Bulut M, et al. Deficiency of a new protein associated with cardiac syndrome X; called adropin. Cardio-vascular therapeutics. 2013;31(3): 174-8.
  31. Yu H-y, Zhao P, Wu M-c, Liu J, Yin W. Serum adropin levels are decreased in patients with acute myocardial infarction. Regulatory peptides. 2014;190:46-9.
  32. Zhang C, Zhao L, Xu W, Li J, Wang B, Gu X, et al. Correlation of serum adropin level with coronary artery disease. Zhonghua yi xue za zhi. 2014;94(16):1255-7.
  33. Topuz M, Celik A, Aslantas T, Demir AK, Aydin S, Aydin S. Plasma adropin levels predict endothelial dysfunction like flow-mediated dilatation in patients with type 2 diabetes mellitus. Journal of investigative medicine. 2013;61(8):1161-4.
  34. Ganesh‐Kumar K, Zhang J, Gao S, Rossi J, McGuinness OP, Halem HH, et al. Adropin deficiency is associated with increased adiposity and insulin resistance. Obesity. 2012;20(7):1394-402.
  35. Butler AA, Tam CS, Stanhope KL, Wolfe BM, Ali MR, O'Keeffe M, et al. Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans. The Journal of Clinical Endocrinology & Metabolism. 2012;97(10):3783-91.
  36. Hamedinia MR, Amiri Parsa T, Azarnive MS, Hosseini Kakhk SAR. The Effect of resistance training, aerobic training and detraining on the lipid profile and CRP in obese girls. Journal of Sabzevar University of Medical Sciences. 2011;18(3):188-97. [In Persian]
  37. Bergholm R. Effects of Weight Loss, Physical Trining and Anti-Inflammatory Therapy on Endothelial Function in Vivo. Department of MedicineDivision of Diabetes University of Helsinki Helsinki, Finland. 2003:1-108.
  38. Skoumas J, Pitsavos C, Panagiotakos DB, Chrysohoou C, Zeimbekis A, Papaioannou I, et al. Physical activity, high density lipoprotein cholesterol and other lipids levels, in men and women from the ATTICA study. Lipids in health and disease. 2003;2(1):1-7.
  39. Isler AK, Kosar S, Korkusuz F. Effects of step aerobics and aerobic dancing on serum lipids and lipoproteins. Journal of sports medicine and physical fitness. 2001; 41(3) :380-5.
  40. Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease: the Framingham Study. The American journal of medicine. 1977;62(5):707-14.
  41. Gaesser GA, Rich RG. Effects of high-and low-intensity exercise training on aerobic capacity and blood lipids. Medicine and science in sports and exercise. 1984;16(3):269-74.
  42. Donovan G, Owen A. Change in cardio respiratorty fitness and coronary disease risk factor following 24 week of equal energy cost. J Appl Physiol. 2005;10:1152-54.
  43. Salehi Z, Salehi K, Moeini M, Kargarfard M, Sadeghi M. The effect of resistance exercise on lipid profile of coronary artery disease patients: a randomized clinical trial. Iranian journal of nursing and midwifery research. 2017; 22 (2): [In Persian]
  44. Saremi A, Asghari M, Ghorbani A. Effects of aerobic training on serum omentin-1 and cardio metabolic risk factors in overweight and obese men. Journal of sports sciences. 2010; 28(9) :993-8.
  45. YE, Xu-Hong. HOU, Xiao-Ping. PAN, Jun-Xi. LU and Wei-Ping. JIA. (2009). Serum vaspin level in relation to postprandial plasma glucose concentration in subjects with diabetes. Chinese Medical Journal. 122:2530-3.
Journal of Applied Health Studies in Sport Physiology
Volume 9, Issue 2
August 2022
Pages 201-212

Files

History

  • Receive Date: 30 July 2022
  • Revise Date: 22 December 2022
  • Accept Date: 22 December 2022

Share

How to cite

Statistics