The effect of high intensity interval training on inflammatory markers in patient with type 2 diabetes: a systematic review and meta-analysis

Document Type : Review Article I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Department of exercise physiology, Faculty of Humanities, University of Kashan, Kashan, Iran University of Kashan

2 Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran

3 Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran

Abstract

Aim:  Type 2 diabetes is associated with increased systemic inflammation that may be increased cardiovascular diseases for which exercise training is a potential therapy. The effects of high intensity interval training (HIIT) on inflammatory markers in Type 2 diabetes patients, however, require further elucidation. We therefore performed a systematic review and meta-analysis to investigate the effect of HIIT on inflammatory markers in Type 2 diabetes patients. Methods:  PubMed, Scopus, and Web of Science were searched up to May 2022 for HIIT vs. Control or only HIIT studies on inflammatory makers i.e. CRP, IL-6 and TNF-α in Type 2 diabetes patients. The search was performed using the HIIT, inflammation and type 2 diabetes keywords. Standardized mean difference (SMD) effect sizes and 95% confidence intervals were calculated using CMA2 software. Results: Among the 257 extracted studies, 11 studies including 257 participants (143 women and 114 men) with an age range of 44 to 71 years were included in the meta-analysis. HIIT was beneficial for promoting a reduction in TNF-a [-0.62 (95% CI: -1.85 to -0.13), p = 0.01] and CRP [-0.65 (95% CI: -1.21 to -0.08), p = 0.02]. However, there were no significant evidence for an effect of HIIT on IL-6 [-0.31 (95% CI: -0.70 to -0.06), p = 0.10] in Type 2 diabetes patients. Conclusions:  These results suggest that HIIT could induce improvements inflammatory cytokines as well as CRP in Type 2 diabetes patients.

Keywords

References

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Journal of Applied Health Studies in Sport Physiology
Volume 9, Issue 2
August 2022
Pages 123-137

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History

  • Receive Date: 14 July 2022
  • Revise Date: 01 September 2022
  • Accept Date: 15 September 2022

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