Effect 8 Week of Combined Aerobic-Resistance Exercise Training on Serum Visfatin Levels and Anthropometric Indices in Obese Young Girls

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 MSc of Exercise Physiology, Department of Sport Sciences, University of Sistan and Baluchestan, Zahedan, Iran.

2 MSc of Exercise Physiology, Department of Sports Physiology and Corrective Movements, Faculty of Sports Sciences, Urmia University, Urmia, Irann.

3 Associate Professor, Department of Sport Sciences, Faculty of Physical Education, University of Sistan and Baluchestan, Zahedan, Iran

Abstract

Aim: Visfatin is a newly discovered adipokine which is highly expressed in visceral adipose tissue and is associated with obesity. But the effect of exercise training on its levels is inconsistent. The aim of this study is to investigate the effect 8 week of combined aerobic-resistance exercise training on serum visfatin levels and anthropometric indices in obese young girls. Methods: 24 obese female university students (mean age 20 to 25 years, body mass index (BMI)≥30 kg/ m2) who did not participated in any regular training program. They had no previous history of cardiovascular and respiratory, renal, surgical, as well as chemical or hormonal drugs. These subjects were randomly divided into combined training (n=12) and control (n=12) groups. The combined exercise training program includes a combination of resistance training (3 sessions per week, 60-80% 1-RM, 7 stations, 3 set 8-12 repetitions), and aerobic training (3 sessions per week, 60 to 80 percent of vo2max, 25 to 40 minutes of activity). For surveying plasma exchanges of visfatin blood samples were taken in fasting state before and after 8 weeks of exercise training. Serum concentrations of visfatin were measured by ELISA using a human kit of Eastibiopharm. Results: Results showed that in combined exercise training group, Visfatin had reduced significantly compared with control groups (p=0/005). Also BMI, weight, waist circumference, WHR in combined exercise training group, compared with control groups reduced significantly (p < 0.05). Conclusion: Overall, it appears that 8 week of combined exercise training can decrease visfatin level in obese young girls through reducing body weight, waist circumference, WHR and body mass index.

Keywords

References

1.    Steinbeck KS. The importance of physical activity in the prevention of overweight and obesity in childhood: a review and an opinion. Obesity reviews. 2001; 2(2): 117-30.
2.    Andersen Lb, Wedderkopp N, Harro M, Klasson-Heggebo L, Sardinha Lb, Et Al. Physical activity levels and patterns of 9-and 15-yr-old European children. Med Sci Sports Exerc. 2004; 36(1): 86-92.
3.    Dang M. Nguyen, Hashem B. El-Serag. The epidemiology of obesity. Gastroenterol Clin North Am. 2010; 39(1): 1–7.
4.    Gelsinger C, Tschoner A, Kaser S, Ebenbichler CF. Adipokine update-new molecules, new functions. Wien Med Wochenschr. 2010; 160(15-16): 377-90.
5.    Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science. 2005; 307(5708): 426-30.
6.    Uslu S, Kebapçı N, Kara M, Bal C. Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus. Experimental and therapeutic medicine. 2012; 4(1): 113-2.
7.    Jorge ML, de Oliveira VN, Resende NM,  Paraiso LF, Calixto A, Diniz ALD, et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism. 2011; 60(9): 1244-52.
8.    Seo DI, So WY, Ha S, Yoo EJ, Kim D, Singh H, et al. effects of 12 weeks of combined exercise training on visfatin and metabolic syndrome factors in obese middle-aged women. J Sports Sci Med. 2011; 10(1): 222-6.
9.    Moravveji A, Sayyah M, Shamsnia E, Vakili Z. Comparing the prolonged effect of interval versus continuous aerobic exercise on blood inflammatory marker of Visfatin level and body mass index of sedentary overweigh/fat female college students. AIMS Public Health. 2019; 6(4):568-576.
10.     Dayani M, Taghian F. Comparison of 12-week Combined Exercise Training on Vitamin D Intake on Serum Visfatin Levels and β-cell Function in Diabetic Overweight Women. Armaghane danesh. 2018; 23 (4): 413-427. [In Persian]
11.     Mir P, Mir Z. Effect of 8 weeks pilates exercise on plasma visfatin and insulin resistance index in obese women. nvj. 2016; 3 (8) :1-1 [In Persian]
12.     Chang, HM, Park HS, Park CY, Song YS, Jang YJ. Association between serum vaspin concentrations and visceral adipose tissue in Korean subjects. Metabolism. 2010; 59(9):1276-81. 
13.     Samara A, Pfister M, Marie B, Visvikis-Siest S. Visfatin, low-grade inflammation and body mass index (BMI). Clin Endocrinol (Oxf). 2008; 69(4): 568-74.
14.     Youn, BS, Klöting, N, Kratzsch, J, Lee N, Park JW, Song ES, et al. Serum vaspin concentrations in human obesity and type 2 Diabetes. Diabetes 2008; 57(2): 372-7.
15.     ChtaraT M. Effects of intra-session concurrent endurance and strength training sequence on aerobic performance and capacity. Br J Sports Med. 2005; 39(8): 555–560.
16.     Choi KM, Kim JH, Cho GJ, Baik SH, Park HS, Kim SM. Effect of exercise training on plasma visfatin and eotaxin levels. Eur J Endocrinol. 2007; 157: PP: 437-442.
17.     Brzycki, M. Strength testing-predicting a one-rep max from reps-to-fatigue. Journal of Physical Education, Recreation & Dance. 1993. 64(1): 88-90.
18.     Berndt J, Klöting N, Kralisch S, Kovacs P, Fasshauer M, Schön MR, Stumvoll M, Blüher M. Plasma visfatin concentrations and fat depot–specific mRNA expression in humans diabetes. Diabetes. 2005; 54(10): 2911-6.
19.     Ha CH, So WY. Effects of combined exercise training on body composition and metabolic syndrome factors. Iran J Public Health. 2012; 41(8): 20-6.
20.     Jackson AS, Pollack ML. Practical assessment of body composition. Phys Sports Med. 1985; 13(1):76-90.
21.     Chen MP, Chung FM, Chang DM, Tsai Jc, Huang Hf , Shin SJ, et al. Elevated plasma level of visfatin/pre –ß cell colony–enhancing factor in patients with type 2 diabetes mellitus. J chin Endocrinol metab. 2006; 91(1): 295-299.
22.     Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment; insulin resistance and beta – cell function from fasting plasma glucose and insulin concentrations in man. Diabeto Logia. 1985; 28(7): 412–419.
23.     Sethi JK and Vidal-Puig A. visfatin: the missing link between intra-abdominal obesity and diabetes? Trends in Molecular Medicine. Trends Mol Med. 2005; 11(8): 344–347.
24.     Sethi JK. Is PBEF/Visfatin/Nampt an Authentic Adipokine Relevant to the Metabolic Syndrome? Current Hypertension Reports 2007; 9(1): 33–38.
25.     Dogru T, Sonmez A, Tasci I, Bozoglu E, Yilmaz MI, Genc H, et al. Plasma visfatin levels in patients with newly diagnosed and untreated type 2 diabetes mellitus and impaired glucose tolerance. Diabetes Res Clin Pract 2007; 76(1): 24-29.
26.     Seifi L, Daryanoosh F, Samadi M. The Effect of 12 Weeks Aerobic Exercise Training on Visfatin, Chemerin Serum Changes in 45-60 year old Obese Women with Type2 Diabetes. JSSU. 2016; 24 (1) :55-64 [In Persian]
27.     Afzalpour M. E, Dasti Gerdi S, THaghebjo M, Hedayati M, Afzalpor MA. Effects of aerobic and resistance training on plasma Visfatin levels in overweight women. 2011; 13(2): 225-32. [In Persian]
28.     Alsabah Alavizadeh N, Hejazi K, Mabhout Moghadam T. Effects of Eight Weeks of Aerobic Exercise on Visfatin, Homocystein, C-reactive protein and Lipid Profile in Sedentary Men. mljgoums. 2018; 12 (4): 29-35.
29.     Zarei M, Hamedinia M, Haghighi A, Noorafshar R, Amini S. Effect of three combined aerobic-resistance exercise training protocols with different intensities on metabolic control and visfatin levels in men with type 2 diabetes. ijdld. 2016; 16 (1): 63-76. [In Persian]
30.     Kralisch S, Klein J, Lossner UBluher M, Paschke R, Stumvoll M, Fasshauer M. Hormonal regulation of the novel adipocytokine visfatin in 3T3–L1 adipocytes. J Endocrinol. 2005; 185(3): R1-8.
31.     DomiehMohammadi A, Khajehlandi A. Effect of 8 weeks endurance training on plasma visfatin in middle aged men. Brazilian Journal of Biom, 2010; 4(3): 174-179.
32.     Isozaki O, sushima T, Miyakawa M, Nozoe Y, Demura H, Seki H. Growth hormone directly inhibits leptin gene expression in visceral fat tissue in fatty Zucker rats. J Endocrinol. 1999; 161(3): 511-6.
 
1.    Steinbeck KS. The importance of physical activity in the prevention of overweight and obesity in childhood: a review and an opinion. Obesity reviews. 2001; 2(2): 117-30.
2.    Andersen Lb, Wedderkopp N, Harro M, Klasson-Heggebo L, Sardinha Lb, Et Al. Physical activity levels and patterns of 9-and 15-yr-old European children. Med Sci Sports Exerc. 2004; 36(1): 86-92.
3.    Dang M. Nguyen, Hashem B. El-Serag. The epidemiology of obesity. Gastroenterol Clin North Am. 2010; 39(1): 1–7.
4.    Gelsinger C, Tschoner A, Kaser S, Ebenbichler CF. Adipokine update-new molecules, new functions. Wien Med Wochenschr. 2010; 160(15-16): 377-90.
5.    Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science. 2005; 307(5708): 426-30.
6.    Uslu S, Kebapçı N, Kara M, Bal C. Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus. Experimental and therapeutic medicine. 2012; 4(1): 113-2.
7.    Jorge ML, de Oliveira VN, Resende NM,  Paraiso LF, Calixto A, Diniz ALD, et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism. 2011; 60(9): 1244-52.
8.    Seo DI, So WY, Ha S, Yoo EJ, Kim D, Singh H, et al. effects of 12 weeks of combined exercise training on visfatin and metabolic syndrome factors in obese middle-aged women. J Sports Sci Med. 2011; 10(1): 222-6.
9.    Moravveji A, Sayyah M, Shamsnia E, Vakili Z. Comparing the prolonged effect of interval versus continuous aerobic exercise on blood inflammatory marker of Visfatin level and body mass index of sedentary overweigh/fat female college students. AIMS Public Health. 2019; 6(4):568-576.
10.     Dayani M, Taghian F. Comparison of 12-week Combined Exercise Training on Vitamin D Intake on Serum Visfatin Levels and β-cell Function in Diabetic Overweight Women. Armaghane danesh. 2018; 23 (4): 413-427. [In Persian]
11.     Mir P, Mir Z. Effect of 8 weeks pilates exercise on plasma visfatin and insulin resistance index in obese women. nvj. 2016; 3 (8) :1-1 [In Persian]
12.     Chang, HM, Park HS, Park CY, Song YS, Jang YJ. Association between serum vaspin concentrations and visceral adipose tissue in Korean subjects. Metabolism. 2010; 59(9):1276-81. 
13.     Samara A, Pfister M, Marie B, Visvikis-Siest S. Visfatin, low-grade inflammation and body mass index (BMI). Clin Endocrinol (Oxf). 2008; 69(4): 568-74.
14.     Youn, BS, Klöting, N, Kratzsch, J, Lee N, Park JW, Song ES, et al. Serum vaspin concentrations in human obesity and type 2 Diabetes. Diabetes 2008; 57(2): 372-7.
15.     ChtaraT M. Effects of intra-session concurrent endurance and strength training sequence on aerobic performance and capacity. Br J Sports Med. 2005; 39(8): 555–560.
16.     Choi KM, Kim JH, Cho GJ, Baik SH, Park HS, Kim SM. Effect of exercise training on plasma visfatin and eotaxin levels. Eur J Endocrinol. 2007; 157: PP: 437-442.
17.     Brzycki, M. Strength testing-predicting a one-rep max from reps-to-fatigue. Journal of Physical Education, Recreation & Dance. 1993. 64(1): 88-90.
18.     Berndt J, Klöting N, Kralisch S, Kovacs P, Fasshauer M, Schön MR, Stumvoll M, Blüher M. Plasma visfatin concentrations and fat depot–specific mRNA expression in humans diabetes. Diabetes. 2005; 54(10): 2911-6.
19.     Ha CH, So WY. Effects of combined exercise training on body composition and metabolic syndrome factors. Iran J Public Health. 2012; 41(8): 20-6.
20.     Jackson AS, Pollack ML. Practical assessment of body composition. Phys Sports Med. 1985; 13(1):76-90.
21.     Chen MP, Chung FM, Chang DM, Tsai Jc, Huang Hf , Shin SJ, et al. Elevated plasma level of visfatin/pre –ß cell colony–enhancing factor in patients with type 2 diabetes mellitus. J chin Endocrinol metab. 2006; 91(1): 295-299.
22.     Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment; insulin resistance and beta – cell function from fasting plasma glucose and insulin concentrations in man. Diabeto Logia. 1985; 28(7): 412–419.
23.     Sethi JK and Vidal-Puig A. visfatin: the missing link between intra-abdominal obesity and diabetes? Trends in Molecular Medicine. Trends Mol Med. 2005; 11(8): 344–347.
24.     Sethi JK. Is PBEF/Visfatin/Nampt an Authentic Adipokine Relevant to the Metabolic Syndrome? Current Hypertension Reports 2007; 9(1): 33–38.
25.     Dogru T, Sonmez A, Tasci I, Bozoglu E, Yilmaz MI, Genc H, et al. Plasma visfatin levels in patients with newly diagnosed and untreated type 2 diabetes mellitus and impaired glucose tolerance. Diabetes Res Clin Pract 2007; 76(1): 24-29.
26.     Seifi L, Daryanoosh F, Samadi M. The Effect of 12 Weeks Aerobic Exercise Training on Visfatin, Chemerin Serum Changes in 45-60 year old Obese Women with Type2 Diabetes. JSSU. 2016; 24 (1) :55-64 [In Persian]
27.     Afzalpour M. E, Dasti Gerdi S, THaghebjo M, Hedayati M, Afzalpor MA. Effects of aerobic and resistance training on plasma Visfatin levels in overweight women. 2011; 13(2): 225-32. [In Persian]
28.     Alsabah Alavizadeh N, Hejazi K, Mabhout Moghadam T. Effects of Eight Weeks of Aerobic Exercise on Visfatin, Homocystein, C-reactive protein and Lipid Profile in Sedentary Men. mljgoums. 2018; 12 (4): 29-35.
29.     Zarei M, Hamedinia M, Haghighi A, Noorafshar R, Amini S. Effect of three combined aerobic-resistance exercise training protocols with different intensities on metabolic control and visfatin levels in men with type 2 diabetes. ijdld. 2016; 16 (1): 63-76. [In Persian]
30.     Kralisch S, Klein J, Lossner UBluher M, Paschke R, Stumvoll M, Fasshauer M. Hormonal regulation of the novel adipocytokine visfatin in 3T3–L1 adipocytes. J Endocrinol. 2005; 185(3): R1-8.
31.     DomiehMohammadi A, Khajehlandi A. Effect of 8 weeks endurance training on plasma visfatin in middle aged men. Brazilian Journal of Biom, 2010; 4(3): 174-179.
32.     Isozaki O, sushima T, Miyakawa M, Nozoe Y, Demura H, Seki H. Growth hormone directly inhibits leptin gene expression in visceral fat tissue in fatty Zucker rats. J Endocrinol. 1999; 161(3): 511-6.
 
Journal of Applied Health Studies in Sport Physiology
Volume 6, Issue 2
August 2019
Pages 65-72

Files

History

  • Receive Date: 06 April 2019
  • Revise Date: 25 May 2019
  • Accept Date: 10 June 2019

Share

How to cite

Statistics