Comparison Effect of Ubiquinone on Stress Oxidative in Athletes and Non-Athletes Men

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Assistant Professor of Exercise Physiology, Department of Physical Education, University of Bonab , Bonab, Iran.

2 Ph.D in Exercise Physiology, Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

Abstract

Aim: Ubiquinone is one of the antioxidants that is prescribed by experts to reduce oxidative damage. The purpose of this study was to compare the effects of ubiquinone supplementation on some oxidative stress indices in athletes and non-athlete men. Methods: In this study, 44 athletic and non-athlete subjects were divided into experimental groups (11 athletes, 11 non-athletes) and controls (11 athletes and 11 non-athletes). First, were taken 5 ml of venous blood. Then, for two weeks a day, 2.5 mg/kg ubiquinone was administered and after 2 weeks, was performed a second stage blood sampling. Results: Serum total antioxidant capacity in non-athletes before taking ubiquinone was 0.84±0.68 and after taking ubiquinone was 1.01±0.86 mmo/ml (P≤0.05). Amount of malondialdehyde, before taking ubiquinone was 2.54±0.28 and after taking ubiquinone was 2.54±0.28 nm ml (P≥0.05). Also in athlete’s mean capacity antioxidation before taking ubiquinone was 0.72±0.18 and after ubiquinone was 0.85±0.34 mmol per ml (P≤0.05) and malondialdehyde before taking ubiquinone was 1.68±0.58 and after taking ubiquinone was 1.64±0.36 nmol/ml (P≥0.05). Conclusion: Consumption of ubiquinone can cause increase antioxidant capacity in athletes and non-athletes. It should be noted that basal levels of total antioxidant capacity and malondialdehyde levels were higher in non-athletes than athletes.

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1. Alessio HM, Hagerman AE, Fulkerson BK, Ambrose J, Rice RE, and Wiley RL. Generation of reactive oxygen species after exhaustive aerobic and isometric exercise. Med Sci Sports Exerc 32 (2000) 1576-1581.
2.Bloomer RJ, Goldfarb AH, Wideman L, McKenzie MJ, and Consitt LA. Effects of acute aerobic and anaerobic exercise on blood markers of oxidative stress. J Strength Cond Res 19 (2005) 276-285.
3.Fisher-Wellman K, and Bloomer RJ. Acute exercise and oxidative stress: a 30 year history. Dyn Med 8 (2009) 1.
4.Urso ML, and Clarkson PM. Oxidative stress, exercise, and antioxidant supplementation. Toxicology 189 (2003) 41-54.
5.Goldfarb AH, McKenzie MJ, and Bloomer RJ. Gender comparisons of exercise-induced oxidative stress: influence of antioxidant supplementation. Appl Physiol Nutr Metab 32 (2007) 1124-1131.
6.Rotig A. News in ubiquinone biosynthesis. Chem Biol 17 (2010) 415-416.
7.Beg S, Javed S, and Kohli K. Bioavailability enhancement of coenzyme Q10: an extensive review of patents. Recent Pat Drug Deliv Formul 4 (2010) 245-255.
8.Gokbel H, Gergerlioglu HS, Okudan N, Gul I, Buyukbas S, and Belviranli M. Effects of coenzyme Q10 supplementation on plasma adiponectin, interleukin-6, and tumor necrosis factor-alpha levels in men. J Med Food 13 (2010) 216-218.
9.Gokbel H, Gul I, Belviranl M, and Okudan N. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. J Strength Cond Res 24 (2010) 97-102.
10. Donrawee L, and Sawattikanon N. Coenzyme Q10 Supplementation Decreases Oxidative Stress and Improves Eur J Pharmacol 600 (2007) 91-98
11.Fu X, Ji R, and Dam J. Antifatigue effect of coenzyme Q10 in mice. J Med Food 13 (2011) 211-215.
12.Gutierrez-Mariscal FM, Perez-Martinez P, Delgado-Lista J, Yubero-Serrano EM, Camargo A, Delgado-Casado N, Cruz-Teno C, Santos-Gonzalez M, Rodriguez-Cantalejo F, Castano JP, Villalba-Montoro JM, Fuentes F, Perez-Jimenez F, and Lopez-Miranda J. Mediterranean diet supplemented with coenzyme Q10 induces postprandial changes in p53 in response to oxidative DNA damage in elderly subjects. Age (Dordr) (2011).
13.Singh RB, Niaz MA, Kumar A, Sindberg CD, Moesgaard S, Littarru GP.2005. Effect on absorption and oxidative stress of different oral Coenzyme Q10 dosages and intake strategy in healthy men. Biofas,25(1-4):219-24.
14.Laaksonen R, Fogelholm M, Himberg JJ, Laakso J, and Salorinne Y. Ubiquinone supplementation and exercise capacity in trained young and older men. Eur J Appl Physiol Occup Physiol 72 (1995) 95-100.
15.Tiano L, Belardinelli R, Carnevali P, Principi F, Seddaiu G, and Littarru GP. Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study. Eur Heart J 28 (2007) 2249-2255.
16. Sohal RS, Kamzalov S, Sumien N, Ferguson M, Rebrin I, Heinrich KR, and Forster MJ. Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice. Free Radic Biol Med 40 (2006) 480-487.
17. Cooke M, Losa M, Boford T, Shelmadine B, Hudson G, Kerksick C, et al. 2008.  Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J of the Inter Soci of Spor Nut. doi:10.1186/1550-2783-2785.
18.Kon M, Kimura F, Akimoto T, Tanabe K, Murase Y, Ikemune S, and Kono I. Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats. Exerc Immunol Rev 13 (2007) 76-88.
19.Kon M, Tanabe K, Akimoto T, Kimura F, Tanimura Y, Shimizu K, Okamoto T, and Kono I. Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. Br J Nutr 100 (2008) 903-909.
20.Kumar A, Singh, R. B, Saxena M.et al. Effect of CarniQgel (ubiquinol and   carnitine) on cytokines in patients with 897 heart failure in the Tishcon study. Acta Cardiol.2007; 62(4): 349−354.
21.Skough K, Krossen C, Heiwe S, Theorell H, and Borg K. (2008). Effects of resistance training in combination with coenzyme Q10 supplementation in patients with post-polio: a pilot study. J Rehabil Med, 40:773-5.