Comparison of the effect of 8 weeks of different exercises (endurance, resistance and combined) on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 MSc of physiology of physical activity and Health, Department of Sports Physiology, Faculty of Physical Education and Sport Sciences, Shahrood University of Technology, Semnan, Iran.

2 Associate Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahrood University of Technology, Semnan, Iran.

3 Assistant Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahrood University of Technology, Semnan, Iran.

Abstract

Aim:  Nesfatin-1 is an adipokine that is secreted from adipose tissue and is involved in the regulation of insulin action and glucose metabolism. The aim of this study was  Comparison the effect of 8 weeks different exercises (endurance, resistance and combined) on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes. Methods: This quasi-experimental study included a pre-test and post-test with 3 experimental groups and one control group. The statistical sample of this research was included of women with type 2 diabetes, with an average age (50.82+6.7 years) and body mass index (29.82+4.35 Kg/m2), That were divided into four groups of 15 people: 1- aerobic training, 2- resistance training, 3- combined training and 4- control group. Blood samples were collected before the beginning of the exercises and 48 hours after the end of the exercises in the fasting state. Dependent T test was used to evaluate intra-group difference, ANOVA test was used to evaluate inter-group difference, significance level p < 0.05. Results: The findings showed that the serum levels of nesfatin-1 in the resistance training groups (p=0.02) and combined training (p=0.009) increased significantly after the intervention, the fasting glucose serum level in the aerobic groups ( (p=0.04) and combined (p=0.04), insulin serum level in the combined group (p=0.007), insulin resistance index in the combined group (p=0.006), serum TG level in aerobic groups (p=0.007) (p=0.006) and combined (p=0.006), LDL serum level in resistance groups (p=0.018) and combined (p=0.001), cholesterol serum level in aerobic groups (p=0.03), resistance (p=0.04) and combined (p=0.02), BMI index in the combined group (p=0.001), body fat percentage also decreased significantly in the combined group (p=0.04). Also, HDL serum levels in the aerobic (p=0.006) and combined (p=0.005) groups and beta cell performance index in the combined group (p=0.001) increased significantly. Conclusions: According to the results of this study, it seems that combined exercises are a more suitable stimulus for increasing nesfatin-1 serum levels and reducing risk factors in women with type 2 diabetes.

Keywords

Main Subjects

Publisher: Azarbaijan Shahid Madani University          Copyright © The Authors   

   

 

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

References

  1. Heng, B.H., et al., The Singapore national healthcare group diabetes registry—Descriptive epidemiology of type 2 diabetes mellitus. Annals Academy of Medicine Singapore, 2010. 39(5): p. 348.
  2. Association, A.D., 2. Classification and diagnosis of diabetes. Diabetes care, 2017. 40(Supplement_1): p. S11-S24.
  3. Schindhelm, R.K., Postprandial dysmetabolism and non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular risk. 2007.
  4. Guariguata, L., et al., Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes research and clinical practice, 2014. 103(2): p. 137-149.
  5. Organization, W.H., World malaria report 2015. 2016: World Health Organization.
  6. Esteghamati, A., et al., Diabetes in Iran: prospective analysis from first nationwide diabetes report of National Program for Prevention and Control of Diabetes (NPPCD-2016). Scientific reports, 2017. 7(1): p. 1-10. [In Persian].
  7. Izadi, M., Top notes of internal medicine gastroenterology 2008 and cecil harrison essential summary 2007. Tehran, Iran: Print Kaleme Prdaz, 2010: p. 118-34. [In Persian].
  8. Bonakdaran, S. and F. Barazandeh Ahmadabadi, Assessment of insulin resistance in idiopathic hirsutism in comparison with Polycystic Ovary Syndrome (PCOS) patients and healthy individuals. medical journal of mashhad university of medical sciences, 2014. 56(6): p. 340-346.
  9. Cho, J.-K., T.-K. Han, and H.-S. Kang, Combined effects of body mass index and cardio/respiratory fitness on serum vaspin concentrations in Korean young men. European journal of applied physiology, 2010. 108(2): p. 347-353.
  10. Ku, Y., et al., Resistance exercise did not alter intramuscular adipose tissue but reduced retinol-binding protein-4 concentration in individuals with type 2 diabetes mellitus. Journal of international medical research, 2010. 38(3): p. 782-791.
  11. Oh-I, S., et al., Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature, 2006. 443(7112): p. 709-712.
  12. Shimizu, H., et al., A new anorexigenic protein, nesfatin-1. Peptides, 2009. 30(5): p. 995-998.
  13. Woods, S.C., et al., Signals that regulate food intake and energy homeostasis. Science, 1998. 280(5368): p. 1378-1383.
  14. Shimizu, H., et al., Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinology, 2009. 150(2): p. 662-671.
  15. Goebel-Stengel, M. and L. Wang, Central and peripheral expression and distribution of NUCB2/nesfatin-1. Current pharmaceutical design, 2013. 19(39): p. 6935-6940.
  16. Ramanjaneya, M., et al., Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinology, 2010. 151(7): p. 3169-3180.
  17. Li, Q.-C., et al., Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans. Regulatory peptides, 2010. 159(1-3): p. 72-77.
  18. Zhang, Z., et al., Increased plasma levels of nesfatin-1 in patients with newly diagnosed type 2 diabetes mellitus. Experimental and clinical endocrinology & diabetes, 2012. 120(02): p. 91-95.
  19. Gonzalez, R., et al., Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats. Endocrinology, 2011. 152(10): p. 3628-3637.
  20. Zhang, A.-Q., et al., Expression of nesfatin-1/NUCB2 in rodent digestive system. World journal of gastroenterology: WJG, 2010. 16(14): p. 1735.
  21. Stengel, A., et al., Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor. Endocrinology, 2009. 150(11): p. 4911-4919.
  22. Tsuchiya, T., et al., Fasting concentrations of nesfatin‐1 are negatively correlated with body mass index in non‐obese males. Clinical endocrinology, 2010. 73(4): p. 484-490.
  23. Kohno, D., et al., Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology, 2008. 149(3): p. 1295-1301.
  24. Stengel, A., et al., Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology, 2009. 150(1): p. 232-238.
  25. Su, Y. and J. Zhang, tang Y, Bi F and liu Jn: the novel function of nesfatin-1: anti-hyperglycemia. Biochem Biophys res commun, 2010. 391: p. 1039-1042.
  26. Ghanbari-Niaki, A., R.R. Kraemer, and R. Soltani, Plasma nesfatin-1 and glucoregulatory hormone responses to two different anaerobic exercise sessions. European journal of applied physiology, 2010. 110(4): p. 863-868. [In Persian].
  27. Tokuyama, Y., et al., Predictors of glycemic control in Japanese subjects with type 2 diabetes mellitus. Metabolism, 2008. 57(4): p. 453-457.
  28. Colberg, S.R., et al., Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes care, 2010. 33(12): p. e147-e167.
  29. Kern, M., et al., Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level. Biochemical Journal, 1990. 270(2): p. 397-400.
  30. Tokmakidis, S.P., et al., The effects of a combined strength and aerobic exercise program on glucose control and insulin action in women with type 2 diabetes. European journal of applied physiology, 2004. 92(4): p. 437-442.
  31. Hopps, E., B. Canino, and G. Caimi, Effects of exercise on inflammation markers in type 2 diabetic subjects. Acta diabetologica, 2011. 48(3): p. 183-189.
  32. Sigal, R.J., et al., Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes care, 2006. 29(6): p. 1433-1438.
  33. Cuff, D.J., et al., Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes care, 2003. 26(11): p. 2977-2982.
  34. Oliveira, C., et al., Combined exercise for people with type 2 diabetes mellitus: a systematic review. Diabetes research and clinical practice, 2012. 98(2): p. 187-198.
  35. Liu, Y., et al., Effects of combined aerobic and resistance training on the glycolipid metabolism and inflammation levels in type 2 diabetes mellitus. Journal of physical therapy science, 2015. 27(7): p. 2365-2371.
  36. Jorge, M.L.M.P., et al., The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism, 2011. 60(9): p. 1244-1252.
  37. Chaudhri, O.B., K. Wynne, and S.R. Bloom, Can gut hormones control appetite and prevent obesity? Diabetes care, 2008. 31(Supplement_2): p. S284-S289.
  38. Chaolu, H., et al., Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice. Experimental and therapeutic medicine, 2011. 2(2): p. 369-373.
  39. Shafipour, Z., A. Daneshjoo, and M. Hoseini, Effect Of Aerobic Training And Walnut Consumption On Nesfatin-1 And Insulin Resistance Index Of Women Type 2 Diabetes. Iranian Journal of Diabetes and Metabolism, 2019. 18(6): p. 334-341. [In Persian].
  40. Mogharnasi, M. and A. Taji Tabas, The Effect of 10 Weeks of Endurance Training of Cycle Ergometer on Nesfatin-1 Levels and Insulin Resistance in Women with Type 2 Diabetes. Journal of Sport Biosciences, 2016. 8(1): p. 95-107. [In Persian].
  41. Soori, R., et al., Effect of 12 weeks resistance training on nesfatn-1 and neuropeptide Y hormones in sedentary obese men. Journal of Practical Studies of Biosciences in Sport, 2019. 7(13): p. 99-111. [In Persian].
  42. Taji Tabas, A. and M. Mogharnasi, The effect of 10 week resistance exercise training on serum levels of nesfatin-1 and insulin resistance index in woman with type 2 diabetes. Iranian journal of Diabetes and Metabolism, 2015. 14(3): p. 179-188. [In Persian].
  43. Association, A.D., Executive summary: Standards of medical care in diabetes—2013. Diabetes care, 2013. 36(Supplement 1): p. S4-S10.
  44. Dianatinasab, A., et al., The effects of aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with metabolic syndrome: A randomized controlled trial. Journal of Exercise Science & Fitness, 2020. 18(3): p. 168-176. [In Persian].
  45. Donyaei, A., F. Shabani, and F. Gholami, Effect of combined training and subsequent detraining on plasma apelin levels in women with type 2 diabetes. Journal of Applied Health Studies in Sport Physiology, 2022. 9(2): p. 37-47. [In Persian].
  46. Ghorbani, M., et al., The effect of 8-weeks compound exercises training with omega-3 and l-carnitine supplementation intake on serum levels of visfatin in type 2 diabetic women. 2017. [In Persian].
  47. Sabzparvar, M., S. Riyahi Malayeri, and B. Divkan, Effect of high-intensity interval training and Aloe vera consumption on serum adiponectin and beta cells function in diabetic male rats. Medical Science Journal of Islamic Azad Univesity-Tehran Medical Branch, 2021. 31(3): p. 299-306. [In Persian].
  48. Babaei, M., et al., The Effect of Aerobic Training and Spirulina on Nesfatin-1 and Peptide YY in Overweight Elderly Men: A randomized trial. Iranian Journal of Health Sciences, 2022. 10(2): p. 48-57. [In Persian].
  49. Amanat, S., et al., A randomized controlled trial on the effects of 12 weeks of aerobic, resistance, and combined exercises training on the serum levels of nesfatin-1, irisin-1 and HOMA-IR. Frontiers in physiology, 2020. 11: p. 562895. [In Persian].
  50. Haghshenas, R., et al., The effect of a 12-week endurance training on IL-6, IL-10 and Nesfatin-1 plasma level of obese male rats. Journal of Sport Biosciences, 2013. 5(4): p. 109-122.
  51. Yang, M., et al., Nesfatin-1 action in the brain increases insulin sensitivity through Akt/AMPK/TORC2 pathway in diet-induced insulin resistance. Diabetes, 2012. 61(8): p. 1959-1968.
  52. Esfarjani, F., F. Rashidi, and S.M. Marandi, The Effect of Aerobic Exercise on Blood Glucose, Lipid Profile and Apo B-100 in Patients with Type II Diabetes. 2013. [In Persian].
  53. Brooks, N., et al., Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. International journal of medical sciences, 2007. 4(1): p. 19.
  54. Choi, K. and Y.-B. Kim, Molecular mechanism of insulin resistance in obesity and type 2 diabetes. The Korean journal of internal medicine, 2010. 25(2): p. 119.
  55. Eghbali, E., S.S. Dadvand, and M. Taheri, The effect of resistance training with and without testosterone injection on plasma levels of nesfatin-1 in adult male rats. Daneshvar Medicine, 2017. 25(3): p. 27-36. [In Persian].
  56. Durstine, J.L., et al., Lipids, lipoproteins, and exercise. Journal of Cardiopulmonary Rehabilitation and Prevention, 2002. 22(6): p. 385-398.
  57. Gorzi, A., et al., Effect of concurrent, strength and endurance training on hormones, lipids and inflammatory characteristics of untrained men. Iranian Journal of Endocrinology and Metabolism, 2012. 13(6): p. 614-620. [In Persian].
Journal of Applied Health Studies in Sport Physiology
Volume 10, Issue 1
April 2023
Pages 83-96

Files

History

  • Receive Date: 14 September 2022
  • Revise Date: 04 January 2023
  • Accept Date: 12 January 2023

Share

How to cite

Statistics