Effect of HIIT and curcumin consumption on serum troponin I and creatine kinase levels in isopretrenol-treated male mice

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license


1 MS Student of Exercise Physiology, Department of Physical Education, Tabriz branch, Islamic Azad University, Tabriz, Iran.

2 Assistant Prof., Department of Exercise Physiology, Tabriz branch, Islamic Azad University, Tabriz, Iran.



Aim:  Regular physical activity can be effective in preventing and rehabilitating cardiovascular disease. The aim of this study was to determine the effect of aerobic training and curcumin consumption on serum troponin I and creatine kinase levels in male rats treated with isopretrenol.  Methods: 40 male rats were randomized in four groups including: control, HIIT, curcumin, HIIT+curcumin. HIIT were conducted for 8 weeks (5 d/w, 60 min/session (with 4 min running at 85-90% of Vo2max and 2 min recovery at 50-60% of Vo2max intervals) and curcumin 15 mg/bw.day, were consumed orally for entire the study period. Results: Only curcumin and Concomitant interventions significantly reduced serum cTnI levels  (P=0.04, P=0.001) and exercise alone had no effect (P=0.44). Also, only the effect of curcumin and  Concomitant (curcumin and HIIT) caused a significant decrease in CK-MB levels (P=0.002, P=0.008). However, HIIT alone had no significant effect on serum CK-MB levels (P=0.27). Conclusion: According to research, HIIT increases the markers of heart damage (troponin I and creatine kinase) and curcumin is able to reduce the markers of heart damage to some extent, However, more researches remains to be done because of the study limitations and lack of similar evidence in myocardial infarction populations.


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