The effect of treadmill aerobic training on adipolin, glucose and insulin in type 2 diabetic male rats

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 MSc in Exercise Physiology, University of Guilan, Rasht, Iran

2 Assistant Professor in Exercise Physiology, University of Guilan, Rasht, Iran.

Abstract

Background and objective: Secretion of pro-inflammatory and anti-inflammatory cytokines play a critical role in the regulation of metabolic conditions. This study examines the effect of eight weeks aerobic training on Adipolin cytokine and insulin resistance index in type 2 diabetic male rats.
Materials and procedures: Eighteen 8-10 weeks Wister rats with 200-220 gr are selected and they divided equaly into two diabetes [DBT] and control [CON] groups randomly. The training program includes 8 weeks of endurance training on a treadmill at a constant dip of 5%. The speed started from 10 meters per minute and it rised to the 25 meters per minute and its time started from 15 minutes to 45 minutes. In end of 8 weeks training, blood samples were taken after 12 hours of fasting in order to determination of insulin, glucose and Adipulin levels. The homeostatic model assessment [HOMA] was calculated as insulin resistance index. The data were analyzed using the an independent t test.
Findings: Comparisons of two groups showed that a meaningful increase in Adipulin and decrease in glucose and insulin resistance.
Conclusion: According to the findings, it seems that aerobic training with moderate intensity will lead to decreasing in insulin resistance and increase in serum levels of Adipulin in type 2 diabetic rats.

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