Effect of branched-chain amino acids supplementation with two different amounts on anabolic hormone response after heavy resistance activity in Paralympic weightlifters

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Rrofessor of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Science, University of Tabriz, Tabriz, Iran

2 Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

3 MSc Student, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran

4 PhD, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran

5 MSc, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

Abstract

A number of physiological stimuli can initiate human growth hormone (hGH) secretion non-pharmacological of which are sleep, amino acid content of the diet and exercise. Therefore, the aim of this research was to evaluate the effect of branched chain amino acids (BCAA) supplementation on hGH and insulin like growth factor (IGF-1) in elite male Paralympic weightlifters. In this semi-experimental study, 21 male Paralympic weightlifters in a randomly and double-blind design were allocated in three equal groups: BCAA group 1 (N=7: 240 mg/kg/day), BCAA group 2 (N=7: 480 mg/kg/day) and placebo group (N=7, dextrose: 120 mg/kg/day). One week before of test, all participants were consumed 120 mg of the BCAA or placebo per kg of body weight. Then, all subjects performed a single bout of resistance exercise (RE). Blood samples were obtained in the 3 phases: 30 minutes prior to RE, 30 minutes post RE and 2 hours post RE. The results showed that BCAA supplementation at doses of 240 and 480 mg/kg/day does not have a significant effect on the response of hGH and IGF-I to upper body resistance exercise in the disabled weightlifters (p>0.05). There was no difference between groups in terms of increased of hormones concentrations (p>0.05).The results of this study appear to support the hypothesis that resistance exercise is a potent physiological stimulus for hGH and IGF-1 secretion, and BCAA supplementation does not increase response of these hormones.

Keywords

Main Subjects

References

1. Koutoukidis G. Tabbner's Nursing Care: Theory and Practice: Elsevier Australia; 2012.
2. Kisner C, Colby LA. Therapeutic exercise: foundations and techniques: FA Davis; 2012.
3. Donachy J, Brannon K, Hughes L, Seahorn J, Crutcher T, Christian E. Strength and endurance training of an 
individual with left upper and lower limb amputations. Disability & Rehabilitation. 2004;26(8):495-9.
4. Burd NA, West DW, Moore DR, Atherton PJ, Staples AW, Prior T, et al. Enhanced amino acid sensitivity of myofibrillar protein synthesis persists for up to 24 h after 
resistance exercise in young men. The Journal of nutrition. 2011;141(4):568-73.
5. McLellan TM, Pasiakos SM, Lieberman HR. Effects of Protein in Combination with Carbohydrate Supplements on Acute or Repeat Endurance Exercise Performance: A Systematic Review. Sports Medicine. 2014;44(4):535-50.
6. Pasiakos SM, McClung HL, McClung JP, Margolis LM, Andersen NE, Cloutier GJ, et al. Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis. The American journal of clinical nutrition. 2011;94(3):809-18.
7. Mottram DR. Drugs in sport: Routledge; 2005.
8. Bompa T, Buzzichelli C. Periodization Training for Sports, 3E: Human Kinetics; 2015.
9. Crewther B, Keogh J, Cronin J, Cook C. Possible stimuli for strength and power adaptation. Sports medicine. 2006;36(3):215-38.
10. Borer KT. Advanced exercise endocrinology: Human Kinetics; 2013.
11. De Palo EF, Gatti R, Lancerin F, Cappellin E, Spinella P. Correlations of growth hormone (GH) and insulin-like growth factor I (IGF-I): effects of exercise and abuse by athletes. Clinica chimica acta. 2001;305(1):1-17.
12. Matthews DE. Observations of branched-chain amino acid administration in humans. The Journal of nutrition. 2005;135(6):1580S-4S.
13. Holeček M. Relation between glutamine, branched-chain amino acids, and protein metabolism. Nutrition. 2002;18(2):130-3.
14. Consitt LA, Copeland JL, Tremblay MS. Hormone responses to resistance vs. endurance exercise in premenopausal females. Canadian journal of applied physiology. 2001;26(6):574-87.
15. Oetken A, Campbell B, La Bounty P, Willoughby D. The effect of BCAA supplementation on serum insulin secretion before, during, and following a lower-body resistance exercise bout. Journal of the International Society of Sports Nutrition. 2008;5(1):1-.
16. Garlick PJ. The role of leucine in the regulation of protein metabolism. The Journal of nutrition. 2005;135(6):1553S-6S.
17. Campbell B, LaBounty P, Oetken A, Greenwood M, Kreider R, Campbell DWB, et al. The anabolic hormone response to a lower-body resistance exercise bout in conjunction with oral BCAA supplementation. METHODS. 2009;2(3):4.
18. Hulmi J. Molecular and hormonal responses and adaptation to resistance and protein nutrition in young and older men. 2009.
19. La Bounty P. The effects of heavy resistance exercise in combination with orally administered branched-chain amino acids or leucine on insulin signaling and Akt/mTOR pathway activity in active males 2007.
20. Ferreira MP, Li R, Cooke M, Kreider RB, Willoughby DS. Periexercise coingestion of branched-chain amino acids and carbohydrate in men does not preferentially augment resistance exercise–induced increases in phosphatidylinositol 3 kinase/protein kinase B–mammalian target of rapamycin pathway markers indicative of muscle protein synthesis. Nutrition Research. 2014;34(3):191-8.
21. Li R, Ferreira MP, Cooke MB, La Bounty P, Campbell B, Greenwood M, et al. Co-ingestion of carbohydrate with branched-chain amino acids or l-leucine does not preferentially increase serum IGF-1 and expression of myogenic-related genes in response to a single bout of resistance exercise. Amino acids. 2015;47(6):1203-13.
22. Campbell B. The effects of branched-chain amino acid and leucine ingestion on the ERK1/2 MAP kinase signal transduction pathway in conjunction with an acute bout of heavy resistance exercise 2007.
23. Glynn EL, Fry CS, Drummond MJ, Timmerman KL, Dhanani S, Volpi E, et al. Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. The Journal of nutrition. 2010;140(11):1970-6.
24. Ratamess NA, Hoffman JR, Ross R, Shanklin M, Faigenbaum AD, Kang J. Effects of an amino acid/creatine energy supplement on the acute hormonal response to resistance exercise. International journal of sport nutrition and exercise metabolism. 2007;17(6):608.
25. De Palo E, Gatti R, Cappellin E, Schiraldi C, De Palo C, Spinella P. Plasma lactate, GH and GH-binding protein levels in exercise following BCAA supplementation in athletes. Amino acids. 2001;20(1):1-11.
26. Willoughby D, Stout J, Wilborn C. Effects of resistance training and protein plus amino acid supplementation on muscle anabolism, mass, and strength. Amino acids. 2007;32(4):467-77.
Journal of Applied Health Studies in Sport Physiology
Volume 5, Issue 1
September 2018
Pages 62-68

Files

History

  • Receive Date: 28 December 2018
  • Revise Date: 19 February 2019
  • Accept Date: 01 April 2019

Share

How to cite

Statistics