Effects of 8 weeks aerobic training on serum level of CTRP9, omentin-1, lipid profile and insulin resistance in inactive obese woman

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 M.Sc. of exercise physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran.

2 Assistant Professor of exercise physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran.

Abstract

One of the positive effects of exercise training is to induce the secretion of useful adipokines from adipose tissue, which play an important role in reducing the risk factors for cardiovascular disease. Therefore, the aim of the present study was to investigate the effect of 8 weeks aerobic training on serum CTRP9, omentin-1, lipid profiles and insulin resistance in obese women. 20 non-active obese women (20-25 years) were randomly divided into two groups (10 subjects) control and training who participated in the study. The training program was run for 8 weeks and 3 sessions per week for 45 to 60 minute. The training and control groups were tested before and after 48 hours after the last training session at week 8 and after 10 to 12 hours of fasting to determine the desired parameters for blood sampling. Data were analyzed using paired t-test and independent t-test at significance level of P

Keywords

Main Subjects


1. Koutnikova H, Genser B, Monteiro-Sepulveda M, Faurie J-M, Rizkalla S, Schrezenmeir J, et al. Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised controlled trials. BMJ Open. 2019;9(3):e017995.
2. Wadey RM, Connolly KD, Mathew D, Walters G, Rees DA, James PE. Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells. Atherosclerosis. 2019;283:19-27.
3. Jaacks LM, Vandevijvere S, Pan A, McGowan CJ, Wallace C, Imamura F, et al. The obesity transition: stages of the global epidemic. The Lancet Diabetes & Endocrinology. 2019.
4. van Meijel RL, Blaak EE, Goossens GH. Adipose tissue metabolism and inflammation in obesity. Mechanisms and Manifestations of Obesity in Lung Disease: Elsevier; 2019. p. 1-22.
5. Unamuno X, Gómez‐Ambrosi J, Rodríguez A, Becerril S, Frühbeck G, Catalán V. Adipokine dysregulation and adipose tissue inflammation in human obesity. European journal of clinical investigation. 2018;48(9):e12997.
6. Pan H-Y, Guo L, Li Q. Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2
53  امنتین  1، پروفایل لیپیدی و مقاومت انسولینی در زنان چاق غیر فعال ،CTRP تاثیر 8 هفته تمرین هوازی بر مقادیر سرمی 9
diabetes. Diabetes research and clinical practice. 2010;88(1):29-33.
7. Watanabe T, Watanabe‐Kominato K, Takahashi Y, Kojima M, Watanabe R. Adipose Tissue‐Derived Omentin‐1 Function and Regulation. Comprehensive Physiology. 2011;7(3):765-81.
8. Pan X, Kaminga AC, Wen SW, Acheampong K, Liu A. Omentin-1 in Diabetes Mellitus: A Systematic Review and Meta-Analysis. Available at SSRN 3353383. 2019.
9. Jia Y, Luo X, Ji Y, Xie J, Jiang H, Fu M, et al. Circulating CTRP9 levels are increased in patients with newly diagnosed type 2 diabetes and correlated with insulin resistance. Diabetes research and clinical practice. 2017;131:116-23.
10. Peterson JM, Aja S, Wei Z, Wong GW. CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition. Journal of Biological Chemistry. 2012;287(2):1576-87.
11. Jung TW, Hong HC, Hwang H-J, Yoo HJ, Baik SH, Choi KM. C1q/TNF-Related Protein 9 (CTRP9) attenuates hepatic steatosis via the autophagy-mediated inhibition of
endoplasmic reticulum stress. Molecular and cellular endocrinology. 2015;417:131-40.
12. Hart A, Johansen KL. Cardiovascular protection and mounting evidence for the benefits of intradialytic exercise. Nephrology Dialysis Transplantation. 2019.
13. Kon M .Ebi Y, Nakagaki K. Effects of a single bout of high-intensity interval exercise on C1q/TNF-related proteins. Applied Physiology, Nutrition, and Metabolism. 2018;44(1):47-51.
14. Saremi A, Asghari M, Ghorbani A. Effects of aerobic training on serum omentin-1 and cardiometabolic risk factors in overweight and obese men. Journal of sports sciences. 2010;28(9):993-8.
15. Daryanoosh F. The effect of 12 weeks of resistance training on the Apelin, Omentin-1 levels and insulin resistance in the elderly overweight women with type 2 diabetes. 2014.
16. Kim H-J, Kim C-H, Lee D-H, Han M-W, Kim M-Y, Ju J-H, et al. Expression of eotaxin in 3T3-L1 adipocytes and the effects of weight loss in high-fat diet induced obese mice. Nutrition research and practice. 2011;5(1):19-1 .
17. Byars A, Greenwood M, Greenwood L, Simpson W. The Effect of Alternating Steady-State Walking Technique on Estimated Vo2max Values of The Rockport Fitness Walking Test in College Students. Journal of Exercise Physiology Online. 2003; 6(2).
18. Kelley GA, Kelley KS, Tran ZV. Aerobic exercise and lipids and lipoproteins in women: a meta-analysis of randomized controlled trials. Journal of women's health. 2004;13(10):1148-64.
19. Moreno-Navarrete JM, Catalán V, Ortega F, Gómez-Ambrosi J, Ricart W, Frühbeck G, et al. Circulating omentin concentration increases after weight loss. Nutrition & metabolism. 2010;7(1):27.
20. Tan BK, Adya R, Farhatullah S, Lewandowski KC, O’Hare P, Lehnert H, et al. Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose. Diabetes. 2008;57(4):801-8.
21. Yang R-Z, Lee M-J, Hu H, Pray J, Wu H-B, Hansen BC, et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. American Journal of Physiology-Endocrinology and Metabolism. 2006;290(6):E1253-E61.
22. Hossain L, Hossain I, Rahman M, Azam M, Afroz M, Hasan M, et al. Circulating omentin-1 levels and its association with insulin resistance in newly diagnosed impaired glucose tolerant subjects. Journal of Diabetology. 2016;7(1):2.
23. Li X, Zeng S, Wang M, Wu X, Liao E. Relationships between serum omentin-1, body fat mass and bone mineral density in healthy Chinese male adults in Changsha area. Journal of endocrinological investigation. 2014;37(10):991-1000.
24. Gürsoy G, Kırnap N, Eşbah O, Acar Y, Demirbaş B, Akçayöz S, et al. The relationship between plasma omentin-1 levels and insulin resistance in newly diagnosed type 2 diabetıc women. Clinical reviews and opinions. 2010;2(4):49-54.
25. Choi HY, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, et al. Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels. Diabetes Care. 2013;36(10):3321-7.
26. Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, Ge G, Spooner E, Hug C, et al. Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. The FASEB Journal. 2009;23(1):241-58.
27. Devlin JT. Effects of exercise on insulin sensitivity in humans. Diabetes care. 1992;15(11):1690-3.