Azarbaijan Shahid Madani University Journal of Applied Health Studies in Sport Physiology 2676-6507 Articles in Press 2026 05 11 Effect of combined resistance and interval training intensity on Irisin level and muscular and aerobic fitness of female with non-alcoholic fatty liver disease (NAFLD) Effect of combined resistance and interval training intensity on Irisin level and muscular and aerobic fitness of female with non-alcoholic fatty liver disease (NAFLD) 15078 10.22049/jahssp.2025.30464.1731 FA Fahimeh Mehrabani Department of Physical Education, Technical and Vocational University (TVU), Tehran, Iran Farhad Rahmaninia Department of Exercise Physiology Javad Mehrabani Dep. Exercise Physiology, University of Guilan Nasrin Razavianzadeh Department of Medical Sciences, Sha.C., Islamic Azad University, Shahrood, Iran Journal Article 2025 04 15 Background& purpose: Non-alcoholic fatty liver disease (NAFLD) occurs due to excessive deposition of fat inside the cytoplasm of hepatocytes, which can lead to simple steatosis, steatohepatitis, fibrosis and cirrhosis. It seems that physical activities are effective in improving fatty liver through the stimulation of myokines. The aim of this study was to evaluate the effect of combined exercises with two intensity modeles on irisin and physical fitness factors in women with fatty liver. Methods: 33 women with NAFLD (age: 43.45±3.75 years) and (body mass index [BMI] 32.84±1.33 kg/m2) were randomly divided into three equal groups: combined interval with moderate intensity aerobic and resistance trainings [MIIA+RT], combined intense interval and resistance trainings [HIIT+RT] and control [CON]. The training program was carried out 3 times a week for 12 weeks. The variables were measured before and after the exercise training program. Data analysis was performed with repeated measure ANOVA and Tukey's post hoc test at a significant level (p<0.05). Results: The findings showed that both HIIT+R and MIIA+R training programs significantly increased irisin (p=0.001; p=0.023), aerobic power (p=0.001; p=0.01), upper (p=0.002; p=0.002) and lower (p=0.01; p=0.03) body maximum strength and endurance (p=0.036; p=0.02) and (p=0.001; p=0.002), but there was no significant change in weight (p=0.061; p=0.052) and BMI (p=0.11; p=0.054). Conclusion: It seems that women with NAFLD can probably use both intensities of combined exercise as a non-pharmacological intervention to improve non-alcoholic fatty liver and physical fitness independent of body weight loss Background& purpose: Non-alcoholic fatty liver disease (NAFLD) occurs due to excessive deposition of fat inside the cytoplasm of hepatocytes, which can lead to simple steatosis, steatohepatitis, fibrosis and cirrhosis. It seems that physical activities are effective in improving fatty liver through the stimulation of myokines. The aim of this study was to evaluate the effect of combined exercises with two intensity modeles on irisin and physical fitness factors in women with fatty liver. Methods: 33 women with NAFLD (age: 43.45±3.75 years) and (body mass index [BMI] 32.84±1.33 kg/m2) were randomly divided into three equal groups: combined interval with moderate intensity aerobic and resistance trainings [MIIA+RT], combined intense interval and resistance trainings [HIIT+RT] and control [CON]. The training program was carried out 3 times a week for 12 weeks. The variables were measured before and after the exercise training program. Data analysis was performed with repeated measure ANOVA and Tukey's post hoc test at a significant level (p<0.05). Results: The findings showed that both HIIT+R and MIIA+R training programs significantly increased irisin (p=0.001; p=0.023), aerobic power (p=0.001; p=0.01), upper (p=0.002; p=0.002) and lower (p=0.01; p=0.03) body maximum strength and endurance (p=0.036; p=0.02) and (p=0.001; p=0.002), but there was no significant change in weight (p=0.061; p=0.052) and BMI (p=0.11; p=0.054). Conclusion: It seems that women with NAFLD can probably use both intensities of combined exercise as a non-pharmacological intervention to improve non-alcoholic fatty liver and physical fitness independent of body weight loss