Azarbaijan Shahid Madani University Journal of Applied Health Studies in Sport Physiology 2676-6507 10 1 2023 03 21 Effect of Resistance Training with Thera-Band on Serum Levels of Netrin-1 and Insulin Resistance Index in Sedentary overweight and Obese Women Effect of Resistance Training with Thera-Band on Serum Levels of Netrin-1 and Insulin Resistance Index in Sedentary overweight and Obese Women 127 140 14521 10.22049/jahssp.2023.28134.1522 FA Seyedeh Motahareh Aletaha MSc student in exercise physiology. Department of physical education, Bojnourd branch, Islamic Azad University, Bojnourd, Iran. Najmeh Rezaeiyan Department of Physical Education Islamic Azad University, Bojnourd Branch, Bojnourd, Iran Journal Article 2022 12 16 <strong>Aim</strong>: Obesity leads to insulin resistance by changing the balance of proteins involved in glucose metabolism, and exercise training can improve glucose hemostasis by effecting obesity. The aim of this study was to investigate the effect of resistance training using thera-band on serum levels of Netrin-1 and insulin resistance index (HOMA-IR) in sedentary overweight and obese women. <strong>Methods</strong> Twenty overweight and obese women (body mass index 32.01±3.01 kg/m², mean aged 44.9±3.43 years) randomly divided into two groups of resistance training and control. Subjects in experimental group participated in eight weeks of resistance training using thera-band, four sessions per week. Blood samples have been taken before and 48 hours after last training session to measure the blood factors assessed. Data analyzed by Co-Variance and P<0.05 considered significant. <strong>Results</strong>: Significant differences existed between training and control groups for serum levels of Netrin-1 (P=0.024) and insulin (P=0.008), HOMA-IR (P=0.009), weight (P=0.001) and body fat percent (P=0.001). <strong>Conclusions</strong>: Resistance training presumably results in decreases in insulin resistance through augmentation of serum Netrin-1 levels in sedentary overweight and obese women. <strong>Aim</strong>: Obesity leads to insulin resistance by changing the balance of proteins involved in glucose metabolism, and exercise training can improve glucose hemostasis by effecting obesity. The aim of this study was to investigate the effect of resistance training using thera-band on serum levels of Netrin-1 and insulin resistance index (HOMA-IR) in sedentary overweight and obese women. <strong>Methods</strong> Twenty overweight and obese women (body mass index 32.01±3.01 kg/m², mean aged 44.9±3.43 years) randomly divided into two groups of resistance training and control. Subjects in experimental group participated in eight weeks of resistance training using thera-band, four sessions per week. Blood samples have been taken before and 48 hours after last training session to measure the blood factors assessed. Data analyzed by Co-Variance and P<0.05 considered significant. <strong>Results</strong>: Significant differences existed between training and control groups for serum levels of Netrin-1 (P=0.024) and insulin (P=0.008), HOMA-IR (P=0.009), weight (P=0.001) and body fat percent (P=0.001). <strong>Conclusions</strong>: Resistance training presumably results in decreases in insulin resistance through augmentation of serum Netrin-1 levels in sedentary overweight and obese women. https://jahssp.azaruniv.ac.ir/article_14521_b4c118ec5e4fbf1800011854bba17519.pdf