Azarbaijan Shahid Madani University Journal of Applied Health Studies in Sport Physiology 2676-6507 10 1 2023 03 21 Comparison of the effect of 8 weeks of different exercises (endurance, resistance and combined) on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes Comparison of the effect of 8 weeks of different exercises (endurance, resistance and combined) on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes 83 96 14511 10.22049/jahssp.2023.27986.1495 FA Roghayeh Koroni MSc of physiology of physical activity and Health, Department of Sports Physiology, Faculty of Physical Education and Sport Sciences, Shahrood University of Technology, Semnan, Iran. Ali Yonesyan Associate Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahrood University of Technology, Semnan, Iran. Adel Donyaei Assistant Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahrood University of Technology, Semnan, Iran. Journal Article 2022 09 14 <strong>Aim:</strong>  Nesfatin-1 is an adipokine that is secreted from adipose tissue and is involved in the regulation of insulin action and glucose metabolism. The aim of this study was  Comparison the effect of 8 weeks different exercises (endurance, resistance and combined) on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes. <strong>Methods</strong>: This quasi-experimental study included a pre-test and post-test with 3 experimental groups and one control group. The statistical sample of this research was included of women with type 2 diabetes, with an average age (50.82+6.7 years) and body mass index (29.82+4.35 Kg/m2), That were divided into four groups of 15 people: 1- aerobic training, 2- resistance training, 3- combined training and 4- control group. Blood samples were collected before the beginning of the exercises and 48 hours after the end of the exercises in the fasting state. Dependent T test was used to evaluate intra-group difference, ANOVA test was used to evaluate inter-group difference, significance level p < 0.05. <strong>Results</strong>: The findings showed that the serum levels of nesfatin-1 in the resistance training groups (p=0.02) and combined training (p=0.009) increased significantly after the intervention, the fasting glucose serum level in the aerobic groups ( (p=0.04) and combined (p=0.04), insulin serum level in the combined group (p=0.007), insulin resistance index in the combined group (p=0.006), serum TG level in aerobic groups (p=0.007) (p=0.006) and combined (p=0.006), LDL serum level in resistance groups (p=0.018) and combined (p=0.001), cholesterol serum level in aerobic groups (p=0.03), resistance (p=0.04) and combined (p=0.02), BMI index in the combined group (p=0.001), body fat percentage also decreased significantly in the combined group (p=0.04). Also, HDL serum levels in the aerobic (p=0.006) and combined (p=0.005) groups and beta cell performance index in the combined group (p=0.001) increased significantly. <strong>Conclusions</strong>: According to the results of this study, it seems that combined exercises are a more suitable stimulus for increasing nesfatin-1 serum levels and reducing risk factors in women with type 2 diabetes. <strong>Aim:</strong>  Nesfatin-1 is an adipokine that is secreted from adipose tissue and is involved in the regulation of insulin action and glucose metabolism. The aim of this study was  Comparison the effect of 8 weeks different exercises (endurance, resistance and combined) on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes. <strong>Methods</strong>: This quasi-experimental study included a pre-test and post-test with 3 experimental groups and one control group. The statistical sample of this research was included of women with type 2 diabetes, with an average age (50.82+6.7 years) and body mass index (29.82+4.35 Kg/m2), That were divided into four groups of 15 people: 1- aerobic training, 2- resistance training, 3- combined training and 4- control group. Blood samples were collected before the beginning of the exercises and 48 hours after the end of the exercises in the fasting state. Dependent T test was used to evaluate intra-group difference, ANOVA test was used to evaluate inter-group difference, significance level p < 0.05. <strong>Results</strong>: The findings showed that the serum levels of nesfatin-1 in the resistance training groups (p=0.02) and combined training (p=0.009) increased significantly after the intervention, the fasting glucose serum level in the aerobic groups ( (p=0.04) and combined (p=0.04), insulin serum level in the combined group (p=0.007), insulin resistance index in the combined group (p=0.006), serum TG level in aerobic groups (p=0.007) (p=0.006) and combined (p=0.006), LDL serum level in resistance groups (p=0.018) and combined (p=0.001), cholesterol serum level in aerobic groups (p=0.03), resistance (p=0.04) and combined (p=0.02), BMI index in the combined group (p=0.001), body fat percentage also decreased significantly in the combined group (p=0.04). Also, HDL serum levels in the aerobic (p=0.006) and combined (p=0.005) groups and beta cell performance index in the combined group (p=0.001) increased significantly. <strong>Conclusions</strong>: According to the results of this study, it seems that combined exercises are a more suitable stimulus for increasing nesfatin-1 serum levels and reducing risk factors in women with type 2 diabetes. https://jahssp.azaruniv.ac.ir/article_14511_8ce39d6d073f1e377f5dd44a9b462858.pdf