Azarbaijan Shahid Madani University Journal of Applied Health Studies in Sport Physiology 2676-6507 8 2 2021 09 23 The effect of intense intermittent exercise on plasma levels of myostatin and IGF-1 in obese adolescents The effect of intense intermittent exercise on plasma levels of myostatin and IGF-1 in obese adolescents 18 24 14296 10.22049/jahssp.2021.27319.1369 FA Sajjad Mohammadyari Assistant Professor, Department of Physical Education, Imam Ali (AS) University, Tehran, Iran. 0000-0003-1844-4032 Hamdollah Hadi Assistant Professor, Department of Physical Education, Amin University of Law Enforcement Sciences, Tehran, Iran. Ahmad Reza Zohrabi Ph.D. Student, Faculty of Sport Sciences, Islamic Azad University, Karaj Branch Journal Article 2021 06 22 <strong>Aim</strong>:   Myostatin and insulin-like growth factor play an important role in responding to muscle contractions, regulating and stimulating muscle metabolism. The aim of this study was to change plasma myostatin and IGF-1 to eight weeks of intense intermittent exercise in obese adolescents.  <strong>Methods</strong>:  This study was a quasi-experimental study and 28 obese adolescents were randomly divided into experimental and control groups. The experimental group performed a very intense intermittent training protocol for eight weeks and three sessions per week. In order to measure the plasma levels of myostatin and IGF-1, blood samples were taken in two stages in the fasting state, 48 hours before and after exercise. A correlated t-test was used for intra-group comparison and an independent t-test was used for comparison between groups. <strong>Results</strong>:   The results showed that after eight weeks of very intense interval training, plasma myostatin levels significantly decreased (P=0.001) and IGF-1 (P=0.013) compared to the control group. <strong>Conclusion</strong>: According to the findings of the present study that a significant reduction of myostatin and the significant increase in IGF-1, high-intensity interval training can be used as a non-pharmacological strategy for prevention and improvement in obese adolescents. <strong>Aim</strong>:   Myostatin and insulin-like growth factor play an important role in responding to muscle contractions, regulating and stimulating muscle metabolism. The aim of this study was to change plasma myostatin and IGF-1 to eight weeks of intense intermittent exercise in obese adolescents.  <strong>Methods</strong>:  This study was a quasi-experimental study and 28 obese adolescents were randomly divided into experimental and control groups. The experimental group performed a very intense intermittent training protocol for eight weeks and three sessions per week. In order to measure the plasma levels of myostatin and IGF-1, blood samples were taken in two stages in the fasting state, 48 hours before and after exercise. A correlated t-test was used for intra-group comparison and an independent t-test was used for comparison between groups. <strong>Results</strong>:   The results showed that after eight weeks of very intense interval training, plasma myostatin levels significantly decreased (P=0.001) and IGF-1 (P=0.013) compared to the control group. <strong>Conclusion</strong>: According to the findings of the present study that a significant reduction of myostatin and the significant increase in IGF-1, high-intensity interval training can be used as a non-pharmacological strategy for prevention and improvement in obese adolescents. https://jahssp.azaruniv.ac.ir/article_14296_e1d5b2b632b5eee9e5aa56adfacbad1e.pdf