Azarbaijan Shahid Madani University Journal of Applied Health Studies in Sport Physiology 2676-6507 6 1 2019 09 23 The Effect of Two Types of High Intensity and Moderate Intensity Continuous Training on Serum Levels of TNF-a and IL-10 in Obese Male Rats The Effect of Two Types of High Intensity and Moderate Intensity Continuous Training on Serum Levels of TNF-a and IL-10 in Obese Male Rats 86 93 13975 10.22049/jassp.2019.26655.1268 FA Amir Akbari PhD Student in Exercise Physiology, Department of Sports Physiology, Faculty of Sports Sciences, University of Guilan, Rasht, Iran. Hamid Mohebbi Professor of Exercise Physiology, Department of Sports Physiology, Faculty of Sports Sciences, University of Guilan, Rasht, Iran. Mousa Khalafi PhD in Exercise Physiology, Department of Sports Physiology, Faculty of Sports Sciences, University of Guilan, Rasht, Iran. 0000-0001-6465-1281 Kamilia Moghaddami Assistant Professor of Exercise Physiology, Department of Sports Science, Faculty of Physical Education, Islamic Of Azad University, Hashtgerd , Hashtgerd, Iran. Journal Article 2019 04 07 <strong>Aim:</strong>The purpose of this study was to investigate the effects of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on inflammatory factors (TNF-α and IL-10) in obese male rats. <strong> Methods:</strong> Forty male rats were divided into two groups: high-fat diet (n=32) and standard diet (n=8), for 10 weeks. After inducing obesity, eight rats from the high-fat diet group (O) and eight from the standard dietary group (C) were sacrificed, and the other obese rats were randomly divided into three groups: obesity control (OC), moderate intensity continuous training (MICT) and high intensity interval training (HIIT). The HIIT protocol, including 10 bouts of 4-minute activity with equivalent intensity of 85-90% vo2max and 2 minute active rest periods, and the MICT protocol with equivalent intensity of 65-70% VO2max, with covered distance matched to that of the HIIT protocol, were performed for 12 weeks and 5 sessions per week. Serum samples were collected to measure serum levels of TNF-α and IL-10 by ELISA. <strong> Results:</strong> In both HIIT and MICT groups, serum levels of TNF-α were significantly decreased and serum levels of IL-10 were significantly increased compared to OC group (p < 0.05). <strong>Conclusions:</strong> But there was no significant difference between the HIIT and MICT groups in serum levels of TNF-α and IL-10. It seems that both HIIT and MICT training protocols improve chronic inflammation by decreasing TNF-α and increasing IL-10. <strong>Aim:</strong>The purpose of this study was to investigate the effects of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on inflammatory factors (TNF-α and IL-10) in obese male rats. <strong> Methods:</strong> Forty male rats were divided into two groups: high-fat diet (n=32) and standard diet (n=8), for 10 weeks. After inducing obesity, eight rats from the high-fat diet group (O) and eight from the standard dietary group (C) were sacrificed, and the other obese rats were randomly divided into three groups: obesity control (OC), moderate intensity continuous training (MICT) and high intensity interval training (HIIT). The HIIT protocol, including 10 bouts of 4-minute activity with equivalent intensity of 85-90% vo2max and 2 minute active rest periods, and the MICT protocol with equivalent intensity of 65-70% VO2max, with covered distance matched to that of the HIIT protocol, were performed for 12 weeks and 5 sessions per week. Serum samples were collected to measure serum levels of TNF-α and IL-10 by ELISA. <strong> Results:</strong> In both HIIT and MICT groups, serum levels of TNF-α were significantly decreased and serum levels of IL-10 were significantly increased compared to OC group (p < 0.05). <strong>Conclusions:</strong> But there was no significant difference between the HIIT and MICT groups in serum levels of TNF-α and IL-10. It seems that both HIIT and MICT training protocols improve chronic inflammation by decreasing TNF-α and increasing IL-10. https://jahssp.azaruniv.ac.ir/article_13975_755bc4972fa9d145fb1e4b2b7c6e3185.pdf