Azarbaijan Shahid Madani University Journal of Applied Health Studies in Sport Physiology 2676-6507 6 2 2019 09 23 The Effect of 8 Weeks of High Intensity Interval Training (HIIT) On Serum Irisin, FGF21 and Glycemic Indices in Type 2 Diabetic Women The Effect of 8 Weeks of High Intensity Interval Training (HIIT) On Serum Irisin, FGF21 and Glycemic Indices in Type 2 Diabetic Women 17 24 13957 10.22049/jassp.2019.26337.1184 FA Leyla Alizadeh MSc. of Exercise Physiology, Department of Sports Physiology, Faculty of Sports Sciences, Urmia University, Urmia, Iran. Asghar Tofighi Associate Professor, Department of Sports Physiology, Faculty of Sports Sciences, Urmia University, Urmia, Iran Javad Tolouei Azar Assistant Professor, Department of Sports Physiology, Faculty of Sports Sciences, Urmia University, Urmia, Iran. Journal Article 2019 05 09 Aim: Due to exercise, Myokines such as Irisin and FGF21 by mediating anti-inflammatory effects, can Effective in progression of insulin resistance caused by type 2 diabetes. thus, the purpose of this study was to investigate the effect of 8 weeks of HIIT on Serum Irisin, FGF21 and Glycemic Indices in Type 2 diabetic women. Methods: 20 diabetic women (age:55.3 and BMI:27.09) were randomly divided into two groups of HIIT and controls (n=10). The HIIT program performed at 3 sessions per week with 85-80% intensity of maximum heart rate for 8 weeks. Blood samples for measured Serum Irisin, FGF21 and glycemic index were taken from two groups in fasting state. Data were analyzed by dependent t-test and independent t-test (p < 0.05). Results: HIIT significantly increased the serum levels of irisin and FGF21 (p=0.001) and decreased HBA1c (p=0.003), glucose and insulin resistance (p= 0.006) in diabetic women after 8 weeks. There was a significant difference between exercise and control group in FGF21 and Irisin and glycemic indices (p=0.001). Conclusion: Based on the results of this study, it seems that HIIT by stimulating the secretion of myokine, such as irisin and FGF21 can effective in controlling glucose homeostasis and insulin resistance. However, with regard the effect of irisin on changes in white and brown adipose tissue, the study of changes in Adipokine with FGF21 and muscle irisin in HIIT is remarkable. Aim: Due to exercise, Myokines such as Irisin and FGF21 by mediating anti-inflammatory effects, can Effective in progression of insulin resistance caused by type 2 diabetes. thus, the purpose of this study was to investigate the effect of 8 weeks of HIIT on Serum Irisin, FGF21 and Glycemic Indices in Type 2 diabetic women. Methods: 20 diabetic women (age:55.3 and BMI:27.09) were randomly divided into two groups of HIIT and controls (n=10). The HIIT program performed at 3 sessions per week with 85-80% intensity of maximum heart rate for 8 weeks. Blood samples for measured Serum Irisin, FGF21 and glycemic index were taken from two groups in fasting state. Data were analyzed by dependent t-test and independent t-test (p < 0.05). Results: HIIT significantly increased the serum levels of irisin and FGF21 (p=0.001) and decreased HBA1c (p=0.003), glucose and insulin resistance (p= 0.006) in diabetic women after 8 weeks. There was a significant difference between exercise and control group in FGF21 and Irisin and glycemic indices (p=0.001). Conclusion: Based on the results of this study, it seems that HIIT by stimulating the secretion of myokine, such as irisin and FGF21 can effective in controlling glucose homeostasis and insulin resistance. However, with regard the effect of irisin on changes in white and brown adipose tissue, the study of changes in Adipokine with FGF21 and muscle irisin in HIIT is remarkable.

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