Azarbaijan Shahid Madani University Journal of Applied Health Studies in Sport Physiology 2676-6507 5 2 2018 09 23 Effects of Pilates training with massage therapy on BDNF and Fatigue index in Women with Multiple Sclerosis Effects of Pilates training with massage therapy on BDNF and Fatigue index in Women with Multiple Sclerosis 84 90 13928 10.22049/jassp.2019.26575.1240 FA Bahloul Ghorbanian Assistant Professor of Sport Science Department, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, IR Iran Akram Mahmood Pour MSc Student of Sport Science Department, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, IR Iran Journal Article 2019 01 27 Brain derived neurotrophic factor (BDNF) is a protein that plays an important role in the maintenance and repair of the nervous system. The purpose of this study was to investigate the effect of 8-weeks of Pilates training with massage on serum BDNF level<br />and fatigue index in women with multiple sclerosis (MS). In this study, 18 volunteer female MS patients (0, diseases history: 4/5; 7±2 years, age: 30-40 years) were randomly divided into Pilates training with massage (n=9) and control (n=9) groups. Training program for Pilates training with massage was carried out for 8 weeks (3 s/wk, consisted of 20 to 40 min Pilates & 20 min massage per session). The BDNF of serum and fatigue index were measured before and after the intervention. Analysis of the data was performed by Paired samples and independent samples t-test by SPSS21 at p < 0.05 statistical significance level. Following to eight weeks of Pilates training with massage, serum BDNF level was significantly increased and fatigue index was significantly decreased (p < 0.05). It seems that Pilates training along with massage could be proposed as a complementary treatment alongside medications to prevent disease progression in MS patients. Brain derived neurotrophic factor (BDNF) is a protein that plays an important role in the maintenance and repair of the nervous system. The purpose of this study was to investigate the effect of 8-weeks of Pilates training with massage on serum BDNF level<br />and fatigue index in women with multiple sclerosis (MS). In this study, 18 volunteer female MS patients (0, diseases history: 4/5; 7±2 years, age: 30-40 years) were randomly divided into Pilates training with massage (n=9) and control (n=9) groups. Training program for Pilates training with massage was carried out for 8 weeks (3 s/wk, consisted of 20 to 40 min Pilates & 20 min massage per session). The BDNF of serum and fatigue index were measured before and after the intervention. Analysis of the data was performed by Paired samples and independent samples t-test by SPSS21 at p < 0.05 statistical significance level. Following to eight weeks of Pilates training with massage, serum BDNF level was significantly increased and fatigue index was significantly decreased (p < 0.05). It seems that Pilates training along with massage could be proposed as a complementary treatment alongside medications to prevent disease progression in MS patients. https://jahssp.azaruniv.ac.ir/article_13928_568ac7b325a1115ee8125f403e6f381e.pdf