Azarbaijan Shahid Madani University Journal of Applied Health Studies in Sport Physiology 2676-6507 4 2 2017 09 23 Investigating The Changes of Irisin and Brain-derived neurotrophic factor Levels due to The Combined Training Investigating The Changes of Irisin and Brain-derived neurotrophic factor Levels due to The Combined Training 10 17 13898 10.22049/jassp.2019.26523.1198 FA Yazgaldi Nazari Ph.D in Exercise Physiology, Shahid Chamran University, Iran. Araz Nazari Department of Physical Education and Sport sciences, Higher Educational Complex of Saravan, Iran. Journal Article 2019 06 12 Abstract <br />Background and Objectives: brain derived neurotrophic factor not only important in the nervous system, but also in central and peripheral molecular processes that related to energy metabolism and homeostasis. Also irisin, a novel myokine that is secreted from skeletal muscles, has an important relationship between physical activity and health. <br />Materials & Methods: In this study, 20 overweight men that were randomly selected and equally divided into control and experimental groups. Blood samples were taken two times, before the start of training, and final samples, 48 hours after the end of the eight-week training.<br />Results: Serum Irisin levels, after the completion of combined training than pre training significantly increased. Also, BDNF levels in the training group, after acute and chronic exercise training significantly increased. But significant correlation between the concentrations of Irisin and BDNF levels of the subjects was not observed.<br />Conclusion: Serum irisin and brain-derived neurotrophic factor levels, influenced by physical activity. Irisin can cause metabolic and physiological changes within the body and play a protective role against conditions such as obesity that associated with inactivity. Likewise, brain-derived neurotrophic factor increased as a result of physical activity and also the critical role in the differentiation of neurons and mental health, do a key role in controlling body weight and energy homeostasis. Abstract <br />Background and Objectives: brain derived neurotrophic factor not only important in the nervous system, but also in central and peripheral molecular processes that related to energy metabolism and homeostasis. Also irisin, a novel myokine that is secreted from skeletal muscles, has an important relationship between physical activity and health. <br />Materials & Methods: In this study, 20 overweight men that were randomly selected and equally divided into control and experimental groups. Blood samples were taken two times, before the start of training, and final samples, 48 hours after the end of the eight-week training.<br />Results: Serum Irisin levels, after the completion of combined training than pre training significantly increased. Also, BDNF levels in the training group, after acute and chronic exercise training significantly increased. But significant correlation between the concentrations of Irisin and BDNF levels of the subjects was not observed.<br />Conclusion: Serum irisin and brain-derived neurotrophic factor levels, influenced by physical activity. Irisin can cause metabolic and physiological changes within the body and play a protective role against conditions such as obesity that associated with inactivity. Likewise, brain-derived neurotrophic factor increased as a result of physical activity and also the critical role in the differentiation of neurons and mental health, do a key role in controlling body weight and energy homeostasis. https://jahssp.azaruniv.ac.ir/article_13898_890b6791051fdc4ade600a738b6b4b65.pdf