اثرات تمرین هوازی، مقاومتی و ترکیبی بر سطوح آدیپونکتین و CTRP9 در بیماران مبتلا به دیابت میلیتوس نوع دو

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 گروه تربیت بدنی و علوم ورزشی، واحد نجف آباد، دانشگاه آزاد اسلامی، نجف آباد، ایران.

2 گروه فیزیولوژی ورزش، دانشکده علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران

10.22049/jahssp.2021.27336.1374

چکیده

هدف: پروتئین 9 مربوط به فاکتور نکروز تومور C1q(CTRP9)، یک آدیپوکین کشف شده جدید و مولکول مهم مربوط به تنظیم متابولیسم گلوکز و لیپید در بیماران دیابتی است. هدف مطالعه حاضر تعیین اثرات تمرین هوازی، مقاومتی و ترکیبی بر سطوح سرمی آدیپونکتین و CTRP9 در بیماران مبتلا به دیابت نوع دو بود.
روش شناسی: 60 مرد بیماران مبتلا به دیابت نوع دو (سن: 26/4±45/51 سال؛ شاخص توده بدن: 01/1±52/31 کیلوگرم بر مجذور قد به متر) به صورت تصادفی در سه گروه تمرین ترکیبی (15 نفر)، گروه هوازی (15 نفر)، مقاومتی (15 نفر) و گروه کنترل (15 نفر) قرار گرفتند. برنامه­های تمرینی شامل تمرین هوازی با شدت (75%-50% ضربان قلب ذخیره بیشینه) و مقاومتی (80%-40% یک تکرار بیشینه) با حجم برابر، 3 بار در هفته، 60 دقیقه در هر جلسه برای مدت 12 هفته بود. سطوح سرمی آدیپونکتین و  CTRP9، قند خون ناشتا، انسولین، مقاومت انسولین در حالت پایه و در پایان مطالعه اندازه­گیری شد. داده­ها با استفاده از تحلیل واریانس با اندازه­گیری تکراری در سطح کمتر از 05/0 مورد تجزیه و تحلیل قرار گرفت.
یافته­ها: پس از 12 هفته مداخله، افزایش معناداری در سطوح سرمی CTRP9 و آدیپونکتین و کاهش معناداری در سطوح پارامترهای قند خون و مقاومت انسولین در گروه­های تمرین ترکیبی، هوازی و مقاومتی در مقایسه با گروه کنترل یافت شد (05/0p<).
نتیجه­گیری: یافته­های مطالعه حاضر نشان داد، 12 هفته تمرین ترکیبی دارای اثرات ضد التهابی بیشتری نسبت به تمرینات هوازی یا مقاومتی است که باعث کاهش معناداری در قند خون ناشتا، انسولین و مقاومت انسولین و افزایش بیشتر در آدیپوکین­های ضد التهابی مانند سطوح آدیپونکتین و CTPR9 در بیماران مبتلا به دیابت نوع دو می­شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effects of Aerobic, Resistance, and Combined Exercise on Adiponectin and CTRP-9 Levels in Patients with Type 2 Diabetes Mellitus

نویسندگان [English]

  • Reza Sadeghi 1
  • saied keshavarz 1
  • Mehdi Kargarfard 2
  • jamshid banaii 1
1 Department of Physical Education and Sport Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
2 Department of Exercise Physiology, Sport Sciences, University of Isfahan, Isfahan, Iran
چکیده [English]

Aim:  The purpose of this study was to determine the effects of aerobic, resistance, and combined exercise on serum levels of adiponectin, CTRP9 and glycemic indexes in patients with T2DM. Methods: Sixty men with T2DM (mean age [X̅±SD]=51.45±4.26 years; body mass index: 31.52±1.01 kg/m2) were randomly assigned to combined  exercise group (CEx: n = 15), aerobic  exercise group (AEx: n = 15), resistance  exercise group (REx: n = 15), and the control group (CON: n= 15). Exercise programs consisted of aerobic exercises at either AEx (50% - 75% of HRR) and REx (40% - 80% of 1-RM), with equal volume, 3 times per week, 60 minutes per session for 12 weeks. Serum levels of adiponectin, CTRP9, fasting blood glucose (FBG), insulin, Insulin resistance (IR) were measured at baseline and at the end of the study. The data were analyzed using repeated-measures analysis of variance at a level less than 0.05. Results: After 12 weeks intervention, serum adiponectin and CTRP5 levels increased significantly, whereas the FBG, insulin, HOMA-IR and BMI levels decreased significantly in the CEx, AEx and Rex groups compared to the control group (P < .05). Conclusion:  The present findings showed that 12-weeks of combined exercise has greater anti-inflammatory effects than aerobic or resistance exercise causing a significant decrease in FBG, insulin and IR and a higher increase in anti-inflammatory adipokines such as adiponectin and CTRP9 levels in T2DM.

کلیدواژه‌ها [English]

  • Diabetes
  • Adiponectin
  • CTRP9
  • Insulin Resistance

   

 

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

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مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 9، شماره 2
مهر 1401
صفحه 173-187

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سابقه مقاله

  • تاریخ دریافت: 26 تیر 1400
  • تاریخ بازنگری: 22 شهریور 1400
  • تاریخ پذیرش: 04 مهر 1400

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