Effect of Resistance Training Combined with Curcumin Supplementation on Expression of Regulatory Genes Related to Myocardial Remodeling in Obese Rats

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Ph.D Student in Exercises Physiology, Department of Physical Education and Sport Sciences, Sport Physiology Department, Islamic Azad University, Larestan Branch, Larestan, Iran

2 Associate Professor in exercises Physiology, Department of exercises Physiology, Islamic Azad University, Marvdasht Branch, Marvdasht, Iran

10.22049/jahssp.2021.26706.1283

Abstract

Aim: Cardiac aging is a major consequence of obesity that results in pathologic cardiac hypertrophy. However, resistance training and curcumin polyphenols can modulate some of involved intracellular signaling pathways. Therefore, the aim of this study was to investigate the effect of resistance training and curcumin supplementation on expression of regulatory genes involved in cardiac structural remodeling. Methods: in this experimental study, 18 male Sprague Dawley rats were divided into Normal Weight Control (n=6), Obese Reference (n = 6), Training + Curcumin (n = 6) groups following to eight weeks of high fat diet consumption. Resistance training were conducted also for eight weeks, three sessions per week against 20 to 50% of body weight. Curcumin (150 mg per kg body weight, daily) was consumed simultaneously through gavage. The expression levels of AMPK, mTOR, S6K, 4EBP, COL1, COL3 and AngII genes were assessed using Real Time-PCR technique and thy data was analyzed by One-way ANOVA. Results: Obesity was lead to AMPK gene expression level downregulation, while expression levels of mTOR, S6K, 4EBP, COL1, COL3, AngII genes were up-regulated (p < 0.05). However; there were also significant differences in expression levels of these genes between Training + Curcumin and Obese Reference groups (p < 0.05). Conclusion: It seems obesity causes acceleration of the processes involved in cardiac pathologic hypertrophy, while resistance training with curcumin supplementation could decrease this hazards to some extent.

Keywords

References

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Journal of Applied Health Studies in Sport Physiology
Volume 7, Issue 2
August 2020
Pages 45-52

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History

  • Receive Date: 26 November 2020
  • Revise Date: 10 January 2021
  • Accept Date: 10 January 2021

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